Journal ArticleDOI
Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation
TLDR
In this paper, the authors performed magnetic resonance imaging on sixty-seven individuals who had never had low-back pain, sciatica, or neurogenic claudication, and found that about one-third of the subjects were found to have a substantial abnormality.Abstract:
We performed magnetic resonance imaging on sixty-seven individuals who had never had low-back pain, sciatica, or neurogenic claudication. The scans were interpreted independently by three neuro-radiologists who had no knowledge about the presence or absence of clinical symptoms in the subjects. About one-third of the subjects were found to have a substantial abnormality. Of those who were less than sixty years old, 20 per cent had a herniated nucleus pulposus and one had spinal stenosis. In the group that was sixty years old or older, the findings were abnormal on about 57 per cent of the scans: 36 per cent of the subjects had a herniated nucleus pulposus and 21 per cent had spinal stenosis. There was degeneration or bulging of a disc at at least one lumbar level in 35 per cent of the subjects between twenty and thirty-nine years old and in all but one of the sixty to eighty-year-old subjects. In view of these findings in asymptomatic subjects, we concluded that abnormalities on magnetic resonance images must be strictly correlated with age and any clinical signs and symptoms before operative treatment is contemplated.read more
Citations
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Journal ArticleDOI
Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.
Alon Lai,Andrew Moon,Devina Purmessur,Branko Skovrlj,Damien M. Laudier,Beth A. Winkelstein,Samuel K. Cho,Andrew C. Hecht,James C. Iatridis +8 more
TL;DR: In vivo painful disc degeneration models with different severities of structural changes may be useful for investigating discogenic pain mechanisms and for screening therapies, although interpretations must note the differences between all surgically induced animal models and the human condition.
Journal ArticleDOI
Behavioral signs of chronic back pain in the SPARC-null mouse.
Imagali Millecamps,Maral Tajerian,E. Helene Sage,E. Helene Sage,E. Helene Sage,Laura S. Stone +5 more
TL;DR: SPARC-null mice display behavioral signs consistent with chronic low back and radicular pain that are attributed to intervertebral disc degeneration, and it is hypothesized that the SPARC- null mouse is useful as a model of chronic back pain due to degenerative disc disease.
Journal ArticleDOI
Evidence for an Inherited Predisposition to Lumbar Disc Disease
Alpesh A. Patel,William Ryan Spiker,Michael D. Daubs,Darrel S. Brodke,Lisa A. Cannon-Albright +4 more
TL;DR: Excess relatedness of affected individuals and elevated risks to both near and distant relatives was observed, strongly supporting a heritable contribution to the development of symptomatic lumbar disc disease.
Journal ArticleDOI
Gait variability measurements in lumbar spinal stenosis patients: part A. Comparison with healthy subjects
Nikos Papadakis,Dimitris G. Christakis,G N Tzagarakis,G I Chlouverakis,Nikolaos A. Kampanis,Konstantinos Stergiopoulos,Pavlos Katonis +6 more
TL;DR: There is a statistically significant difference between gait variability in the control group and the experimental group, and ROC analysis determines a cut-off differential entropy value.
Journal ArticleDOI
Risk factors for a recurrence of low back pain
Mark J. Hancock,Chris M. Maher,Peter Petocz,Chung-Wei Christine Lin,Daniel Steffens,Alejandro Luque-Suarez,John Magnussen +6 more
TL;DR: The findings suggest that pathology seen on MRI plays a potentially important role in recurrence of LBP, which should be further investigated in larger trials.
References
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Journal ArticleDOI
Back pain and sciatica.
TL;DR: Low back pain is usually a self-limiting symptom, but it costs at least $16 billion each year and disables 5.4 million Americans, and the fact that a benign physical condition has such an importa...
Journal ArticleDOI
A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients.
TL;DR: To study the type and number of CAT scan abnormalities of the lumbar spine that occur in asymptomatic people, 52 studies from a control population with no history of back trouble were mixed randomly with six scans from patients with surgically proven spinal disease, and all were interpreted by three neuroradiologists in a blinded fashion.
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Abnormal myelograms in asymptomatic patients.
TL;DR: The incidence of myelographic abnormalities in 300 patients who were studied by posterior fossa myelography to establish a diagnosis of acoustic tumor is reported, even though patients had no symptoms of cervical or lumbar nerve root compression at the time of the examination.
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The question of lumbar discography.
TL;DR: It has not been established whether internal derangement of the lumbar disc is sufficiently symptom-producing to be a therapeutic objective, especially a surgical one, or whether it represetits anything more than an aging process, and the patterns of degeneration seen in 628 of 2,187 discs injected by the Cleveland group and 773 of 6,784 discs injections by Feinberg or 322 of 870 disc injected by Massie and Stevens may represent nothing more than normal patterns for the age
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Lumbar herniated disk disease and canal stenosis: prospective evaluation by surface coil MR, CT, and myelography
TL;DR: The results of this study indicate that a technically adequate MR examination was equivalent to CT and myelography in the diagnosis of lumbar canal stenosis and herniated disk disease.