Journal ArticleDOI
Access and utilization of long chain fatty acyl-CoA by zDHHC protein acyltransferases.
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TLDR
In this article , the details of fatty acyl-CoA recognition by zDHHC acyltransferases using insights from the recent structure are discussed. But, the authors do not discuss the potential mechanisms that underlie the potential mechanism for fat-coA compartmentalization and intracellular transport.About:
This article is published in Current Opinion in Structural Biology.The article was published on 2022-09-29. It has received 2 citations till now. The article focuses on the topics: Medicine & Acyltransferases.read more
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Journal ArticleDOI
CellPalmSeq: A curated RNAseq database of palmitoylating and de-palmitoylating enzyme expression in human cell types and laboratory cell lines
Angela R. Wild,Peter Hogg,Stephane Flibotte,Shruti Kochhar,Rocio Hollman,Kurt Haas,Shernaz X. Bamji +6 more
TL;DR: The CellPalmSeq (https://cellpalmseq.med.ubc.ca), a curated RNAseq database and interactive web tool for visualization of the expression patterns of the genes that regulate palmitoylation across human single cell types, bulk tissue, cancer cell lines and commonly used laboratory non-human cell lines as discussed by the authors .
Posted ContentDOI
Palmitoylation of the Hemagglutinin of Influenza B virus by ER-localized DHHC enzymes 1, 2, 4 and 6 is essential for virus replication
Xiao Juan Meng,Michael Veith +1 more
TL;DR: In this article , a comparison of predicted and experimentally determined protein structures suggests that the exclusive acylation of the Influenza B virus with palmitate is not a function of the responsible DHHCs.
References
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Journal ArticleDOI
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.
TL;DR: The central role of lipid chaperones — the fatty acid-binding proteins (FABPs) — in lipid-mediated biological processes and systemic metabolic homeostasis through the regulation of diverse lipid signals is discussed, and their therapeutic significance is highlighted.
Journal ArticleDOI
Palmitoylation: policing protein stability and traffic
TL;DR: Recent studies that have provided insights into the mechanisms that mediate the functional consequences of palmitate are reviewed.
Journal ArticleDOI
Structural classification of zinc fingers: survey and summary.
TL;DR: A comprehensive classification of zinc finger spatial structures is presented and it is found that each available zinc finger structure can be placed into one of eight fold groups that are defined based on the structural properties in the vicinity of the zinc-binding site.
Journal ArticleDOI
Catalytic triads and their relatives
Guy Dodson,Alexander Wlodawer +1 more
TL;DR: Review of these enzymes shows that the acid-base-ser/thr pattern of catalytic residues is generally conserved, although the individual acids and bases can vary.
Journal ArticleDOI
Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal
Zeina Chamoun,Randall K. Mann,Denise Nellen,Doris P. von Kessler,Manolo Bellotto,Philip A. Beachy,Konrad Basler +6 more
TL;DR: A segment polarity gene in Drosophila melanogaster, skinny hedgehog(ski), is identified, and it is shown that its product is required in Hh-expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues.
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