Journal ArticleDOI
Acoustic and Elastic Properties of Glycerol in Oil-Based Gel Phantoms
Luciana C. Cabrelli,Felipe Wilker Grillo,Diego R. T. Sampaio,Antonio A. O. Carneiro,Theo Z. Pavan +4 more
TLDR
Glycerol dispersion in oil-based gels is proposed to modify the acoustic and elastic properties of copolymer-in-oil phantoms and opens the possibility of incorporating other oil-insoluble substances to control further properties of the phantom.Abstract:
Phantoms are important tools for image quality control and medical training. Many phantom materials have been proposed for ultrasound; most of them use water as the solvent, but these materials have disadvantages such as dehydration and low temporal stability if not properly stored. To overcome these difficulties, copolymer-in-oil gel was proposed as an inert and stable material; however, speed of sound for these materials is still lower than what is described for most biological tissues. Here, we propose the glycerol dispersion in oil-based gels to modify the acoustic and elastic properties of copolymer-in-oil phantoms. We manufactured copolymer-in-oil gels using styrene-ethylene/butylene-styrene (SEBS) in concentrations 8%–15%. We used 2 types of mineral oils with different viscosities. Glycerol was added in a volume fraction 0%–30% of the total amount of liquid. The acoustic ( i.e., speed of sound, attenuation and backscattering) and the mechanical ( i.e., density and Young's modulus) properties of the samples were within the range of values observed for soft tissues. The acoustic parameters of the samples were dependent on oil viscosity and glycerol concentration. The speed of sound ranged 1423 m/s – 1502 m/s, while the acoustic attenuation and the ultrasonic backscattering increased by adding glycerol. The density and the Young's moduli were less affected by the presence of glycerol. We conclude that glycerol can be used to control the acoustic parameters of copolymer-in-oil gels. Additionally, it opens the possibility of incorporating other oil-insoluble substances to control further properties of the phantom.read more
Citations
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Journal ArticleDOI
Tissue mimicking materials for imaging and therapy phantoms: a review.
Conor K. McGarry,Lesley J Grattan,Aoife M. Ivory,Francesca Leek,Gary P Liney,Yang Liu,Piero Miloro,Robba Rai,A P Robinson,Albert J. Shih,Bajram Zeqiri,Catharine H. Clark +11 more
TL;DR: This review investigates the specifications that are typically being used in development of the latest TMMs and investigates the imaging modalities that have been investigated focus around CT, mammography, SPECT, PET, MRI and ultrasound.
Journal ArticleDOI
Synthesis and characterization of zinc substituted magnetite nanoparticles and their application to magneto-motive ultrasound imaging
Yaser Hadadian,Diego R. T. Sampaio,Ana Paula Ramos,Antonio Adilton Oliveira Carneiro,Morteza Mozaffari,Luciana C. Cabrelli,Theo Z. Pavan +6 more
TL;DR: In this article, Zn-substituted magnetic nanoparticles with aim of enhancing the saturation magnetization were successfully synthesized by the coprecipitation method and the effect of zinc on morphology, structure and magnetic properties of the prepared nanoparticles was studied and their potential for MMUS imaging was investigated.
Journal ArticleDOI
Tissue-mimicking materials for elastography phantoms: A review
TL;DR: A brief overview of the typical phantom materials reported in the literature is provided and the progress made in recent years and the open issues that deserve further investigation are discussed.
Journal ArticleDOI
Subwavelength Focusing Beam and Superresolution Ultrasonic Imaging Using a Core-shell Lens
José P. Leão-Neto,G. S. Cardoso,Alisson S. Marques,Marco A. B. Andrade,Júlio Cezar Adamowski,Theo Z. Pavan,Glauber T. Silva,J. H. Lopes +7 more
TL;DR: In this paper, a core-shell shaped lens was used to enhance the subwavelength properties of the focusing beam of an ultrasound imaging system, which can double the spatial resolution and increase the focal depth.
Journal ArticleDOI
Criteria for the design of tissue-mimicking phantoms for the standardization of biophotonic instrumentation
Lina Hacker,Heidrun Wabnitz,Antonio Pifferi,T. Joshua Pfefer,Brian W. Pogue,Sarah E. Bohndiek +5 more
TL;DR: In this article , the authors discuss general criteria for the design of tissue-mimicking biophotonic phantoms, and use these criteria and state-of-the-art developments to critically review the literature on phantom materials and on the fabrication of phants.
References
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Book
Biomechanics: Mechanical Properties of Living Tissues
Yuan-Cheng Fung,Richard Skalak +1 more
TL;DR: This chapter discusses the mechanics of Erythrocytes, Leukocytes, and Other Cells, and their role in Bone and Cartilage, and the properties of Bioviscoelastic Fluids, which are a by-product of these cells.
Journal ArticleDOI
Biomechanics: Mechanical Properties of Living Tissues
Yuan-Cheng Fung,Richard Skalak +1 more
TL;DR: In this article, the authors present a sketch of the history and scope of the field of bio-physiology and discuss the meaning of the Constitutive Equation and the flow properties of blood.
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Elastic Moduli of Breast and Prostate Tissues under Compression
TL;DR: To evaluate the dynamic range of tissue imaged by elastography, the mechanical behavior of breast and prostate tissue samples subject to compression loading has been investigated and the data show that breast fat tissue has a constant modulus over the strain range tested while the other tissues have a modulus that is dependent on the strain level.
Journal ArticleDOI
Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry
TL;DR: This review is an attempt to indicate which sets of phantoms are optimal for specific applications, and provide links to studies that characterize main phantom material properties and recipes.
Journal ArticleDOI
A review of tissue substitutes for ultrasound imaging.
TL;DR: This paper reviews ultrasound tissue-mimicking materials and phantom fabrication techniques that have been developed over the past four decades, and describes the benefits and disadvantages of the processes.
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