Activity of Five Aminoglycoside Antibiotics In Vitro Against Gram-Negative Bacilli and Staphylococcus aureus
TLDR
BB-K8 generally showed the greatest ratio between achieveable mean peak serum levels and concentrations needed to inhibit each group of organisms tested and was active against six of seven highly gentamicin-resistant strains.Abstract:
The in vitro susceptibility to BB-K8, butirosin, gentamicin, sisomicin, and tobramycin of seven groups of clinically significant gram-negative bacilli and Staphylococcus aureus was assessed by using the International Collaborative Study-World Health Organization criteria. The activity of gentamicin, sisomicin, and tobramycin generally paralleled each other. Sisomicin was the most potent compound by weight and usually demonstrated the most rapid rate of killing. BB-K8 and butirosin were less potent, but higher serum levels may be achieved with these agents. BB-K8 generally showed the greatest ratio between achieveable mean peak serum levels and concentrations needed to inhibit [Formula: see text] of each group of organisms tested. Additionally, BB-K8 was active against six of seven highly gentamicin-resistant strains. All of these antibiotics showed diminished activity at pH 6.4 but only gentamicin and sisomicin showed occasionally enhanced activity at pH 8.4.read more
Citations
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Controlled comparison of amikacin and gentamicin.
TL;DR: The results indicate that amikacin is effective against severe gram-negative infections and is not more and not less ototoxic or nephrotoxic than gentamicin.
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Creeping baselines and adaptive resistance to antibiotics
TL;DR: This review summarizes the available information on adaptive resistance and proposes that this type of resistance could be the key to understanding the failure of some antibiotic therapy programs, although adaptive resistance mechanisms are still somewhat unexplored.
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Tobramycin: A Review of its Antibacterial and Pharmacokinetic Properties and Therapeutic Use
TL;DR: Tobramycin is a new aminoglycoside antibiotic with a broad antibacterial spectrum in vitro, and pharmacokinetic properties similar to those for gentamicin, and appears to offer no clear advantages over gentamicIn against sensitive organisms it is indicated in infection caused by strains of P. aeruginosa.
Journal ArticleDOI
Comparative efficacy and toxicity of amikacin/carbenicillin versus gentamicin/carbenicillin in leukopenic patients: A randomized prospective trail
William K. Lau,Lowell S. Young,Robert E. Black,Drew J. Winston,Stuart R. Linné,Ralph J. Weinstein,William L. Hewitt +6 more
TL;DR: Improved survival in both treatment groups was associated with the use of combinations of drugs that interacted synergistically in vitro, and a regimen which incorporates carbenicillin and either drug is equally effective, but empiric use of amikacin is indicated when there is a reasonable possibility of infection due to gentamicin-resistant organisms.
References
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