Journal ArticleDOI
Actual causes of death in the United States.
J M McGinnis,W H Foege +1 more
TLDR
The most prominent contributors to mortality in the United States in 1990 were tobacco, diet and activity patterns, alcohol, microbial agents, toxic agents, firearms, sexual behavior, motor vehicles, and illicit use of drugs.Abstract:
Objective. —To identify and quantify the major external (nongenetic) factors that contribute to death in the United States. Data Sources. —Articles published between 1977 and 1993 were identified through MEDLINE searches, reference citations, and expert consultation. Government reports and compilations of vital statistics and surveillance data were also obtained. Study Selection. —Sources selected were those that were often cited and those that indicated a quantitative assessment of the relative contributions of various factors to mortality and morbidity. Data Extraction. —Data used were those for which specific methodological assumptions were stated. A table quantifying the contributions of leading factors was constructed using actual counts, generally accepted estimates, and calculated estimates that were developed by summing various individual estimates and correcting to avoid double counting. For the factors of greatest complexity and uncertainty (diet and activity patterns and toxic agents), a conservative approach was taken by choosing the lower boundaries of the various estimates. Data Synthesis. —The most prominent contributors to mortality in the United States in 1990 were tobacco (an estimated 400000 deaths), diet and activity patterns (300 000), alcohol (100 000), microbial agents (90 000), toxic agents (60 000), firearms (35 000), sexual behavior (30 000), motor vehicles (25 000), and illicit use of drugs (20 000). Socioeconomic status and access to medical care are also important contributors, but difficult to quantify independent of the other factors cited. Because the studies reviewed used different approaches to derive estimates, the stated numbers should be viewed as first approximations. Conclusions. —Approximately half of all deaths that occurred in 1990 could be attributed to the factors identified. Although no attempt was made to further quantify the impact of these factors on morbidity and quality of life, the public health burden they impose is considerable and offers guidance for shaping health policy priorities. (JAMA. 1993;270:2207-2212)read more
Citations
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Journal ArticleDOI
Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study
Vincent J. Felitti,Robert F. Anda,Dale F. Nordenberg,David F. Williamson,Alison M. Spitz,Valerie J. Edwards,Mary P. Koss,James S. Marks +7 more
TL;DR: For example, this article found a strong relationship between the breadth of exposure to abuse or household dysfunction during childhood and multiple risk factors for several of the leading causes of death in adults.
Journal ArticleDOI
Physical Activity and Public Health: A Recommendation From the Centers for Disease Control and Prevention and the American College of Sports Medicine
Russell R. Pate,Michael Pratt,Steven N. Blair,William L. Haskell,Caroline A. Macera,Claude Bouchard,David Buchner,Walter H. Ettinger,Gregory W. Heath,Abby C. King,Andrea M. Kriska,Arther S. Leon,Bess H. Marcus,Jeremy N. Morris,Ralph S. Paffenbarger,Kevin Patrick,Michael L. Pollock,James Rippe,James F. Sallis,Jack H. Wilmore +19 more
TL;DR: Every US adult should accumulate 30 minutes or more of moderate-intensity physical activity on most, preferably all, days of the week.
Journal ArticleDOI
Actual causes of death in the United States, 2000.
TL;DR: These analyses show that smoking remains the leading cause of mortality in the United States, however, poor diet and physical inactivity may soon overtake tobacco as the lead cause of death.
Journal ArticleDOI
Selected major risk factors and global and regional burden of disease
TL;DR: Substantial proportions of global disease burden are attributable to these major risks, to an extent greater than previously estimated.
Journal ArticleDOI
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle,Rudolf Kaaks +1 more
TL;DR: Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
References
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Book
Cancer : Principles and Practice of Oncology
TL;DR: Part I: Molecular Biology of Cancer Molecular Methods in Oncology Section 1. Amplification Techniques Section 2. RNA Interference Section 3. cDNA arrays Section 4. Tissue arrays Section 5. Cytogenetics Section 6. Bioinformatics Genomics and Proteomics Molecular Targets in oncology.
Book
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Richard Doll,Richard Peto +1 more
TL;DR: Evidence that the various common types of cancer are largely avoidable diseases is reviewed, and it is suggested that, apart from cancer of the respiratory tract, the types of cancers that are currently common are not peculiarly modern diseases and are likely to depend chiefly on some long-established factor.
Journal ArticleDOI
Health inequalities among British civil servants: the Whitehall II study
Michael Marmot,Stephen Stansfeld,Chandrakant R. Patel,Fiona M North,Jenny Head,Ian R. White,Eric J. Brunner,A Feeney,G. Davey Smith +8 more
TL;DR: There was an inverse association between employment grade and prevalence of angina, electrocardiogram evidence of ischaemia, and symptoms of chronic bronchitis, and self-perceived health status and symptoms were worse in subjects in lower status jobs.
Journal ArticleDOI
Socioeconomic status and health: how education, income, and occupation contribute to risk factors for cardiovascular disease.
TL;DR: Higher education may be the best SES predictor of good health, and the relationship between these SES measures and risk factors was strongest and most consistent for education, showing higher risk associated with lower levels of education.
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