Acute experimental canine ehrlichiosis. I. Sequential reaction of the hemic and lymphoreticular systems.
M. J. Reardon,K. R. Pierce +1 more
TLDR
Dogs with acute Ehrlichia canis infection showed the established clinical features of acute ehrlichiosis and had thrombocytopenia, anemia, increased serum glutamic pyruvic transaminase activity, and decreased total serum protein and albumin concentrations during the first weeks after infection, and increasing gamma globulin concentrations after the third week.Abstract:
Dogs with acute Ehrlichia canis infection showed the established clinical features of acute ehrlichiosis and had thrombocytopenia, anemia, increased serum glutamic pyruvic transaminase activity, and decreased total serum protein and albumin concentrations during the first weeks after infection, and increasing gamma globulin concentrations after the third week.Gross lesions in hemic and lymphoreticular tissues were transient lymphadenomegaly, splenomegaly, and increased red long-bone marrow. Lymphoreticular hyperplasia in the paracortical area of lymph nodes and in the splenic red pulp occurred during the second week of infection. Later, small lymphocytes were replaced by medium-sized lymphocytes and plasma cells. Activity of germinal centers increased initially, as shown by numerous mitotic figures and macrophages, but diminished later, and the follicles blended with interfollicular and paracortical tissue because of a decrease in small lymphocytes in the mantle layer. We saw splenic hemorrhages near the ...read more
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Human infection with Ehrlichia canis, a leukocytic rickettsia
TL;DR: Five main antigenic groups that cause Typhus, spotted fever, scrub typhus, Q Fever, Q fever, and trench fever are identified.
Journal ArticleDOI
Ehrlichial diseases of dogs.
Benny J. Woody,Johnny D. Hoskins +1 more
TL;DR: Information on each Ehrlichial diseases of dogs' history, transmission, pathogenesis, clinicopathologic findings, diagnosis, therapy, and prevention is presented in this article.
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Experimental infection and co-infection of dogs with Anaplasma platys and Ehrlichia canis: hematologic, serologic and molecular findings
Stephen D. Gaunt,Melissa J. Beall,Brett A. Stillman,Leif Lorentzen,Pedro Diniz,Ramaswamy Chandrashekar,Edward B. Breitschwerdt +6 more
TL;DR: The results of this study demonstrate that simultaneous or sequential infection with A. platys and E. canis can alter various pathophysiological parameters in experimentally infected dogs, and because natural exposure to multiple tick-borne pathogens occurs frequently in dogs, awareness of co-infection is important in clinical practice.
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Significance of serological testing for ehrlichial diseases in dogs with special emphasis on the diagnosis of canine monocytic ehrlichiosis caused by Ehrlichia canis.
TL;DR: The review emphasizes that the disease process, cross-reactivites with other ehrlichial species, multiple tick-borne infections and persistent IFA antibody titers post-treatment, should all be considered when interpreting E. canis serological results.
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Experimental acute canine monocytic ehrlichiosis: clinicopathological and immunopathological findings.
Márcio Botelho de Castro,Rosangela Zacarias Machado,Lucia Padilha Cury Tomaz de Aquino,Antonio Carlos Alessi,Mirela Tinucci Costa +4 more
TL;DR: Immunophenotyping of lymphocytes from lymph nodes and spleen sections displayed alterations in IgG, IgM, CD3+ and CD8+ cells population in infected dogs, and the main lesions were lymphoreticular hyperplasia and centrolobular fatty degeneration of the liver.
References
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A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
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Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia.
Journal Article
A Comparative Study of the Pathology of Scrub Typhus (Tsutsugamushi Disease) and Other Rickettsial Diseases
Arthur C. Allen,Sophie Spitz +1 more
Journal ArticleDOI
Serological Diagnosis of Tropical Canine Pancytopenia by Indirect Immunofluorescence
Miodrag Ristic,Miodrag Ristic,D L Huxsoll,D L Huxsoll,Rita M. Weisiger,Rita M. Weisiger,Paul K. Hildebrandt,Paul K. Hildebrandt,Mramba Nyindo,Mramba Nyindo +9 more
TL;DR: An indirect fluorescent-antibody test for detection and titration of antibodies to Ehrlichia canis, the causative agent of tropical canine pancytopenia, has been described.