scispace - formally typeset
Open AccessJournal ArticleDOI

Acute myeloid leukemia: survival analysis of patients at a university hospital of Paraná

Reads0
Chats0
TLDR
Prognostic factors strongly influenced patient survival, as well as guided treatment, and these factors were consistent with the available literature adjusted for the population in question.
Abstract
a b s t r a c t Objective: The aim of this study was to analyze the prognostic factors correlated with survival of patients with acute myeloid leukemia at the Hospital de Clinicas, Universidade Federal do Parana between 2003 and 2009, as well as to investigate the clinical and epidemiological profile. Methods: The overall survival and disease-free survival were statistically evaluated using the Kaplan–Meier method, the log-rank test and multivariate evaluation by Cox regression analysis. Results: The study population was predominantly younger than 60 years old (81,6%), had intermediate cytogenetic risk (40.8%), in first complete remission after induction chemotherapy (46.9%), with a white blood count at diagnosis of less than 30 × 109/L (57.1%) and de novo

read more

Citations
More filters
Journal ArticleDOI

Survival outcomes of CD34+CD38-LSCs and their expression of CD123 in adult AML patients.

TL;DR: It is elucidated that CD34+CD38-LSCs, with or without CD123+ LSCs phenotype was present in a significant proportion of AML patients and it could be responsible for resistance to traditional treatments, and high percentage of MRD that was translated into significantly high number of non CR, poor DFS, and OS.
Journal ArticleDOI

Pilot Study of an Integrative New Tool for Studying Clinical Outcome Discrimination in Acute Leukemia.

TL;DR: A multifactorial analysis which integrates clinical parameters, ex vivo tumor characterization and behavioral in vivo analysis in zebrafish to understand leukemic primary cells behavior and features associated with aggressiveness and metastatic potential is proposed.
Journal Article

High expression of dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1) is associated with poor prognosis in acute myeloid leukemia.

TL;DR: The findings indicated that high expression of DUSP5P1 may identify high-risk AML patients and is associated with poor prognosis in AML.
Journal ArticleDOI

Access to Therapy for Acute Myeloid Leukemia in the Developing World: Barriers and Solutions.

TL;DR: The barriers to access therapy from a clinician point of view are analyzed, to show that most DC shared similar challenges but with a diverse healthcare structure, and several possible solutions for a more integrated and timely treatment are provided.
References
More filters
Book

WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues

TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI

Cancer statistics, 2012

TL;DR: The reduction in overall cancer death rates since 1990 in men and 1991 in women translates to the avoidance of about 1,024,400 deaths from cancer, which can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket.
Journal ArticleDOI

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

TL;DR: The 2016 edition of the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition.
Journal ArticleDOI

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia: A Report of the French-American-British Cooperative Group

TL;DR: The first proposals for the morphologic classification of the acute leukemias by the French-American-British (FAB) group were put forward in the hope that they might serve as a basis for future studies.
Related Papers (5)