Journal ArticleDOI
Adaptive regulation of wall shear stress to flow change in the canine carotid artery
Akira Kamiya,Tatsuo Togawa +1 more
TLDR
To study the adaptive response of the vascular wall to blood flow changes, an arteriovenous shunt was constructed between the common carotid artery and the external jugular vein in 12 dogs and showed that r increased with increased flow load and vice versa.Abstract:
To study the adaptive response of the vascular wall to blood flow changes, an arteriovenous shunt was constructed between the common carotid artery and the external jugular vein in 12 dogs. Six to eight months postoperatively, the arterial internal radius (r) was determined by angiography and/or the use of pressure-volume relationship. The results showed that r increased with increased flow load (f) and vice versa. Wall shear rate (gamma) was calculated from gamma = 4f/(tau r3), assuming laminar flow. The value of gamma, initially proportional to f, had recovered almost to the control level (within 15%) due to the vessel dilatation or atrophy during the chronic experiment, when f was less than 4 times the control. Transendothelial protein permeability, evaluated at the T-1824-stained surface by a reflectometric method, also showed a close correlation with wall shear (r = 0.934). A local autoregulatory mechanism of wall shear stress involving protein turnover in the vascular wall is suggested.read more
Citations
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Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
TL;DR: The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.
Journal ArticleDOI
Flow-mediated endothelial mechanotransduction
TL;DR: The transmission of hemodynamic forces throughout the endothelium and the mechanotransduction mechanisms that lead to biophysical, biochemical, and gene regulatory responses of endothelial cells to hemodynamic shear stresses are reviewed.
Journal ArticleDOI
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives
Jeng Jiann Chiu,Shu Chien +1 more
TL;DR: Current knowledge on the role of disturbed flow in EC physiology and pathophysiology, as well as its clinical implications are summarized to contribute to the understanding of the etiology of lesion development in vascular niches with disturbed flow and help to generate new approaches for therapeutic interventions.
Journal ArticleDOI
Blood flow in arteries
TL;DR: The study of arterial blood flow will lead to the prediction of individual hemodynamic flows in any patient, the development of diagnostic tools to quantify disease, and the design of devices that mimic or alter blood flow.
Journal ArticleDOI
Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms : Results From the Prospective Multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) Study
Bon-Kwon Koo,Andrejs Erglis,Joon Hyung Doh,David V. Daniels,Sanda Jegere,Hyo-Soo Kim,Allison Dunning,Tony DeFrance,Alexandra J. Lansky,Jonathan Leipsic,James K. Min +10 more
TL;DR: Noninvasive FFR derived from CCTA is a novel method with high diagnostic performance for the detection and exclusion of coronary lesions that cause ischemia.
References
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Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.
TL;DR: It appears that wall shear rate may be a major controlling factor in the development of atheromatous lesions in man and in animals and a net flux of cholesterol from blood to wall cannot account for the observed normally occurring (quasi-steady state) and experimentally induced atheroma.
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Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients
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Localization of atheroma: a theory based on boundary layer separation.
TL;DR: The development of atheroma is undoubtedly related to hypertension as well as to lipid disturbance, and it has not hitherto been possible to suggest a way in which they might be related.
Journal ArticleDOI
Microvascular dimensions and blood flow in skeletal muscle.
Elof Eriksson,Rhagnar Myrhage +1 more
TL;DR: In cats anesthetized with chloralose the lengths and diameters of the different vascular segments in the tenuissimus muscle were measured in the vital microscope and the flow characteristics, including red cell velocity, were registered.