Adenosine diphosphate-induced platelet aggregation and vascular injury in swine and rabbits.

TLDR: Examination of sections at various times after ADP infusion, by light and electron microscopv, found that platelet aggregates in flowing blood may initiate damage of the normal vessel wall 5', and give rise to vasculitis.

Abstract: IN THE LAST CENTURY it was shown that vessel injurv leads to the formation of platelet thrombi.1' Recent observations, however, indicate that the opposite sequence mav take place, viz, that platelet aggregates in flowing blood may initiate damage of the normal vessel wall 5', and give rise to vasculitis, as reported by Hughes and Tonks.7 Platelet aggregates in flowing blood can be produced by infusion of adenosine diphosphate (ADP). 12 These platelet aggregates are rapidly reversible,89 and the question arises as to whether vascular damage can be produced bv transient platelet aggregates. This problem was explored in the present study by examining sections at various times after ADP infusion, by light and electron microscopv.