Journal ArticleDOI
Adjusted ionized calcium (at pH 7.4) and actual ionized calcium (at actual pH) in capillary blood compared for clinical evaluation of patients with disorders of calcium metabolism
TLDR
Adjusted ionized calcium is found to be as useful as actual ionization calcium for evaluation of patients with disorders of calcium metabolism and may therefore be a logical choice for establishing agreement between laboratories for reference intervals in healthy adults.Abstract:
We report results for adjusted ionized calcium (at pH 7.4) and actual ionized calcium (at actual pH) in capillary blood from 183 patients with disorders of calcium metabolism (primary hyperparathyroidism, secondary hyperparathyroidism of malabsorption, primary hypoparathyroidism, Paget's disease, acromegaly, hypercalcemia of malignancy, osteoporosis, sarcoidosis, idiopathic hypercalciuria, and familial hypocalciuric hypercalcemia). The correlation and the equation for the linear regression between adjusted ionized calcium (y) and actual ionized calcium (x) were y = 1.011x + 0.005 mmol/L, r = 0.992, Sy,x = 0.021 mmol/L. Results were similar within each diagnostic group. Consistent agreement between adjusted and ionized calcium was observed in 96.7% of patients representing a variety of the most frequently encountered disorders of calcium metabolism. Thus we find adjusted ionized calcium to be as useful as actual ionized calcium for evaluation of patients with such disorders. Adjusted ionized calcium may therefore also be a logical choice for establishing agreement between laboratories for reference intervals in healthy adults.read more
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Ion Selective Electrodes (ISEs) and interferences--a review.
TL;DR: Ion Selective Electrodes are used to measure some of the most critical analytes on clinical laboratory and point-of-care analysers and they are not free of interferences.
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Invited critical reviewIonized calcium
TL;DR: Controversy in the literature as to whether direct measurement of ionized calcium, measurement of total (free plus chelated or protein-bound) calcium, or adjustment of total calcium for albumin concentration is the best or most practical clinical measure of calcium is reviewed, as the three methods differ in costs and clinical sensitivities.
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The Importance of Measuring Ionized Calcium in Characterizing Calcium Status and Diagnosing Primary Hyperparathyroidism
Gregory S. Y. Ong,John P. Walsh,Bronwyn G. A. Stuckey,Suzanne J. Brown,Enrico Rossi,Jennifer L. Ng,Hieu Nguyen,G. Neil Kent,Ee Mun Lim +8 more
TL;DR: In abnormal calcium states, tCa frequently disagrees with iCa in classifying calcium status, and Measurement of iCa is required to accurately assess calcium status and improve diagnostic accuracy.
Journal ArticleDOI
New Whole Blood Analyzers and Their Impact on Cardiac and Critical Care
TL;DR: The hybrid laboratory (a composite of conventional clinical laboratory and patient-focused testing), performance maps, and quality paths facilitate implementation of new whole blood analyzers for optimal support of cardiac and critical care, and improved patient outcomes.
Journal ArticleDOI
Evaluation of Clinical and Clinical Chemical Parameters in Periparturient Cows
TL;DR: Clinical symptoms like mood, appetite, muscle shivering, rumen motility, and paresis were individually correlated with blood calcium and were thereby predictive of hypocalcemia, showing the central role of calcium in affecting the clinical symptoms.