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African Swine Fever Virus
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African swine fever was first described in 1921 by Montgomery, who reported several disease outbreaks of domestic pigs in Kenya since 1910 with a mortality close to 100%.Abstract:
African swine fever (ASF) was first described in 1921 by Montgomery, who reported several disease outbreaks of domestic pigs in Kenya since 1910 with a mortality close to 100%. Montgomery recognized the viral nature of the disease, its likely transmission by wild swine which probably acted as virus carriers, and the lack of protection by passive immunization [1]. ASF is a menace to the pig population in the world because there is no vaccine, the virus multiplies in ticks and mutates easily, and different virus isolates can produce diseases with different clinical forms or no disease at all. The control and eradication of ASF require rapid diagnosis, drastic slaughter, and quarantine.read more
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Journal ArticleDOI
Common Origin of Four Diverse Families of Large Eukaryotic DNA Viruses
TL;DR: The conservation of the disulfide-oxidoreductase, a major capsid protein, and two virion membrane proteins indicates that the odd-shaped virions of poxviruses have evolved from the more common icosahedral virion seen in asfarviruses, iridoviruses, and phycodnaviruses.
Journal ArticleDOI
African swine fever: how can global spread be prevented?
Solenne Costard,Barbara Wieland,William A. de Glanville,Ferran Jori,Rebecca J. Rowlands,Wilna Vosloo,François Roger,Dirk U. Pfeiffer,Linda K. Dixon +8 more
TL;DR: The introduction of ASF to Georgia in the Caucasus in 2007 and dissemination to neighbouring countries emphasizes the global threat posed by ASF and further increases the risks to other countries.
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African swine fever virus replication and genomics
TL;DR: African swine fever virus (ASFV) is a large icosahedral DNA virus which replicates predominantly in the cytoplasm of infected cells and a similar mechanism of replication to Poxviruses has been proposed for ASFV.
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Epidemiology of African swine fever virus
TL;DR: African swine fever virus has high morbidity in naïve pig populations and can result in very high mortality, and there is no vaccine or treatment available.
Journal ArticleDOI
Tick-borne viruses
Milan Labuda,Patricia A. Nuttall +1 more
TL;DR: Key challenges are to determine the molecular adaptations that allow tick-borne viruses to infect and replicate in both tick and vertebrate cells, and to identify the principal ecological determinants oftick-borne virus survival.
References
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Proteins Specified by Herpes Simplex Virus V. Purification and Structural Proteins of the Herpesvirion
TL;DR: An evaluation of the purification procedure and the results of analyses of the virion proteins by high-resolution acrylamide gel electrophoresis indicated that viral proteins range from 25,000 to 275,000 daltons, which corresponds to 47% of the genetic information of the virus.
Journal Article
Hemadsorption and cytopathic effect produced by African Swine Fever virus in swine bone marrow and buffy coat cultures.
W. A. Malmquist,D. Hay +1 more
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Incompletely base-paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain
TL;DR: Self-priming and de novo start replication models, which involve a site-specific nick in one DNA strand proximal to the 104 nucleotide loop, account for the observed sequence inversions and incomplete base-pairing.
Journal ArticleDOI
Density gradients prepared from colloidal silica particles coated by polyvinylpyrrolidone (Percoll)
TL;DR: A new gradient medium (Percoll) for density gradient centrifugation of cells and subcellular particles which consists of colloidal silica particles which have been firmly coated with a layer of polyvinylpyrrolidone, which has a high solubility and forms clear solutions.