L
Lakshminarayan M. Iyer
Researcher at National Institutes of Health
Publications - 35
Citations - 12980
Lakshminarayan M. Iyer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Comparative genomics. The author has an hindex of 22, co-authored 32 publications receiving 11902 citations. Previous affiliations of Lakshminarayan M. Iyer include Texas A&M University & University of Michigan.
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Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Complete genome sequence of the apicomplexan, Cryptosporidium parvum.
Mitchell S. Abrahamsen,Thomas J. Templeton,Shinichiro Enomoto,Juan E. Abrahante,Guan Zhu,Cheryl A. Lancto,Mingqi Deng,Chang Liu,Giovanni Widmer,Saul Tzipori,Gregory A. Buck,Ping Xu,Alan T. Bankier,Paul H. Dear,Bernard Anri Konfortov,Helen Spriggs,Lakshminarayan M. Iyer,Vivek Anantharaman,L. Aravind,Vivek Kapur +19 more
TL;DR: Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients in the parasite, which lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome.
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Evolutionary history and higher order classification of AAA+ ATPases.
TL;DR: The AAA+ class appears to have undergone an early radiation into the clamp-loader, DnaA/Orc/Cdc6, classic AAA, and "pre-sensor 1 beta-hairpin" (PS1BH) clades and may provide new leads for investigating the biology of AAA+ ATPases.
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The many faces of the helix-turn-helix domain: Transcription regulation and beyond
TL;DR: This reconstruction suggests that there were at least 6-11 different HTH domains in the last universal common ancestor of all life forms, which covered much of the structural diversity and part of the functional versatility of the extant representatives of this domain.
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Evolutionary genomics of Nucleo-Cytoplasmic Large DNA Viruses
TL;DR: It is shown that subsequent evolution of the NCLDV genomes involved lineage-specific expansion of paralogous gene families and acquisition of numerous genes via horizontal gene transfer from the eukaryotic hosts, other viruses, and bacteria (primarily, endosymbionts and parasites).