Open AccessJournal Article
Alcohol sensitivity, alcohol metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes.
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This article is published in Journal of Laboratory and Clinical Medicine.The article was published on 1993-09-01 and is currently open access. It has received 53 citations till now. The article focuses on the topics: Alcohol tolerance & Alcohol dehydrogenase.read more
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Journal ArticleDOI
DNA Damage, DNA Repair, and Alcohol Toxicity—A Review
TL;DR: The goal of this review is to integrate recent results from the fields of mutagenesis and DNA repair with the alcohol toxicity literature, with the aim of stimulating research into the role of DNA damage in different types of alcohol toxicity and therole of DNA repair in protecting cells from alcohol-related damage.
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Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for body mass
Paul Y. Kwo,Vijay A. Ramchandani,Sean O'Connor,Deborah Amann,Lucinda G. Carr,Kumar Sandrasegaran,Kenyon K. Kopecky,Ting-Kai Li +7 more
TL;DR: Women have greater clearance of ethanol per unit lean body mass, confirming previous oral alcohol administration studies, and explaining the equivalent alcohol elimination rates seen when men and women are compared on the basis of liver size.
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Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework
TL;DR: The present evidence-based review suggests that the physiological range of ethanol elimination rates from blood is from 10 to 35 mg/100mL/h, which can hopefully serve as best-practice guidelines when questions arise in criminal and civil litigation about the elimination rate of ethanol from blood in humans.
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Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence.
San Yuan Huang,Wei-Wen Lin,Huei Chen Ko,Jia-Fu Lee,Tso-Jen Wang,Yuan-Hwa Chou,Shih-Jiun Yin,Ru Band Lu +7 more
TL;DR: ANX/DEP ALC is a specific subtype of alcohol dependence and the DRD2 gene was not found to be associated with pure alcohol dependence or ANx/DEP, but was found to been associated with ANX/DEV ALC.
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Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians
TL;DR: These results are consistent with genetic linkage studies showing protective associations for alcohol dependence and related behavior on chromosome 4 and suggest that ADH2 polymorphisms may account for these findings.