Journal ArticleDOI
Alpha- and beta-adrenergic receptor subtypes properties, distribution and regulation.
TLDR
The effects of catecholamines in the central and peripheral nervous systems appear to be mediated through interactions with two major classes of receptor: α-adrenoceptors and β-adsensors as mentioned in this paper.Abstract:
The effects of catecholamines in the central and peripheral nervous systems appear to be mediated through interactions with 2 major classes of receptor: α-adrenoceptors and β-adrenoceptors. Subtypes of both α- and β-adrenoceptors exist. In the periphery, α1-receptors are located postsynaptically, mediating the excitatory effects of catecholamines at α-receptors. α2-Adrenoceptors, on the other hand, are autoreceptors involved in the regulation of noradrenaline (norepinephrine) release. In the central nervous system, both α1- and α2-receptors exist on postsynaptic cells; there are also 2 principal subtypes of β-adrenoceptors. β1-Receptors have a high affinity for both noradrenaline and adrenaline (epinephrine) and are found in the heart, brain, and adipose tissue. β2-Receptors have a low affinity for noradrenaline and are involved in mediation of relaxation of vascular and other smooth muscles and in many of the metabolic effects of catecholamines.read more
Citations
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Journal ArticleDOI
Cellular magnesium homeostasis.
TL;DR: The present review is aimed at providing the reader with a comprehensive and up-to-date understanding of the mechanisms enacted by eukaryotic cells to regulate cellular Mg(2+) homeostasis and how these mechanisms are altered under specific pathological conditions.
Journal ArticleDOI
Regulation of cellular magnesium.
Andrea Romani,Antonio Scarpa +1 more
TL;DR: The present review will attempt to update knowledge in this area and provide some insights on how changes in cellular Mg2+ content can result in a modification of the activity rate for several cellular enzymes.
Journal ArticleDOI
Locus coeruleus: a new look at the blue spot.
Gina R. Poe,Stephen L. Foote,Oxana Eschenko,Joshua P. Johansen,Sebastien G. Bouret,Gary Aston-Jones,Carolyn W. Harley,Denise Manahan-Vaughan,David Weinshenker,Rita J. Valentino,Craig W. Berridge,Daniel J. Chandler,Barry D. Waterhouse,Susan J. Sara,Susan J. Sara +14 more
TL;DR: Major compelling questions about the functional role of the locus coeruleus nucleus that had been difficult to answer, given its remote location and diminutive size have now become accessible via new neuroscience tools.
Journal ArticleDOI
Drugs in exacerbation of psoriasis.
TL;DR: Clinical, histologic, and biochemical evidence for drug-associated onset or exacerbation of psoriasis, including lithium, beta adrenergic receptor blocking agents, and antimalarials is evaluated.
Journal ArticleDOI
Hormonal control of Mg2+ transport in the heart
Andrea Romani,Antonio Scarpa +1 more
TL;DR: It is shown that noradrenaline, through β-adrenergic stimulation and increase of cyclic AMP, stimulates a large efflux of Mg2+ from cardiac cells, and this transport is of major dimensions and can move up to 20% of total cellular Mg 2+ within a few minutes.
References
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The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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A study of the adrenotropic receptors
TL;DR: Experiments described in this paper indicate that although there are two kinds of adrenotropic receptors they cannot be classified simply as excitatory or inhibitory since each kind of receptor may have either action depending upon where it is found.
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Differentiation of receptor systems activated by sympathomimetic amines.
TL;DR: The classification of receptor systems which are activated by sympathomimetic amines has engaged the attention of many investigators as mentioned in this paper, who have suggested the convenient designations of alpha (α) and beta (β) to distinguish major differences in the responses elicited in various organ systems.