Journal ArticleDOI
Alterations of factor VIII von Willebrand factor in clinical conditions associated with an increase in its plasma concentration.
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TLDR
Factor VIII‐related antigen (VIIIR: Ag) was consistently higher than factor‐VIII procoagulant activity (VIII:C) in 57 patients with clinical conditions characterized by acute‐phase reactions.Abstract:
Summary. Factor VIII-related antigen (VIIIR: Ag) was consistently higher than factor-VIII procoagulant activity (VIII:C) in 57 patients with clinical conditions characterized by acute-phase reactions. Two different methods for measuring VIII:C (one- and two-stage assays) and VIIIR: Ag (electroimmunodiffusion and immunoradiometric assay) gave concordant results in the majority of cases. In 43% of plasma samples, crossed immunoelectrophoresis in agarose gel was characterized by the appearance of an additional, fast-moving precipitin peak which was immunologically identical with the major, slower-moving VIIIR : Ag peak. The fast-moving peak was detected in all the patients with clinical conditions typically associated with increased plasma proteolysis (DIC, acute pancreatitis, during thrombolytic therapy). It was present in a smaller proportion of cases with liver and renal failure and malignancies and in the post-operative period. The additional VIIIR : Ag peak is thought to be the result of in vivo factor VIII/von Willebrand factor fragmentation by proteolytic enzymes.read more
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Journal ArticleDOI
von Willebrand factor and von Willebrand disease
TL;DR: The von Willebrand factor (vWF) is a multimeric glycoprotein that mediates platelet adhesion and aggregation onto thrombogenic surfaces, and functioning as carrier in plasma for the factor VIII procoagulant protein this paper.
Journal ArticleDOI
Vascular toxicity associated with antineoplastic agents
TL;DR: Vascular complications associated with antineoplastic agents are being reported with increasing frequency and putative mechanisms for such toxicity include drug-induced endovascular damage, perturbation of the clotting system, platelet activation, an abnormality of thromboxane-prostacyclin homeostasis, autonomic dysfunction, vasculitis, and stimulation of fibroblasts.
Journal ArticleDOI
von Willebrand factor is an acute phase reactant in man
TL;DR: Plasma von Willebrand factor antigen (vWfAg) concentrations in 19 patients with acute infectious illnesses of bacterial, viral or parasitic origin were significantly elevated with a mean greater than 3-fold above normal, and is thus an acute phase reactant in man.
Journal ArticleDOI
Bleeding in renal failure.
TL;DR: Les causes d'hemorragie dans l'uremie: anemie, facteur de von Willebrand, interactions plaquettaires, hormone parathyroidienne, thromboxane A 2 et prostacycline, dDAVP, œstrogenes conjugues.
Journal ArticleDOI
Loss of the largest von Willebrand factor multimers from the plasma of patients with congenital cardiac defects
TL;DR: Some patients with noncyanotic congenital heart disease may have an acquired abnormality of vWF that is normalized with correction of the abnormal hemodynamic state, according to analysis of the factor VIII molecular complex.
References
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Journal ArticleDOI
Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-Von Willebrand factor bound to the subendothelium.
TL;DR: Evidence is presented that factor VIII–VWF binds to subendothelium of human arteries and that subendOThelium-bound factor VIII-Von Willebrand factor complex mediates the platelet adhesion.
Book ChapterDOI
Acute-Phase Reactants
TL;DR: The term acute phase reactants (AP-reactants) as discussed by the authors is used to refer to protein components of plasma whose concentration is significantly increased in the acute phase of inflammatory processes.
Journal ArticleDOI
Decreased adhesion of platelets to subendothelium in von Willebrand's disease
Thomas B. Tschopp,Thomas B. Tschopp,Harvey J. Weiss,Harvey J. Weiss,H. R. Baumgartner,H. R. Baumgartner +5 more
TL;DR: Impaired adhesion of platelets to some component of the blood vessel wall may account for the prolonged bleeding time in patients with von Willebrand's disease.
Journal ArticleDOI
Active release of human platelet factor VIII-related antigen by adenosine diphosphate, collagen, and thrombin.
TL;DR: It is reported that platelet-contained VIIIR:Ag is released from platelets by collagen, ADP and thrombin, and mechanisms by which platelet:Ag may contribute to the primary events of hemostasis are suggested.
Journal Article
Studies on the prolonged bleeding time in von Willebrand's disease.
TL;DR: The hypothesis that factor VIII may exert its effect on primary hemostasis locally in the vessel wall, VIIIAGN and its relationship with the bleeding time were studied by direct immunofluorescence in gum-biopsy specimens obtained in vWd patients before cryoprecipitate infusion.