Book ChapterDOI
Acute-Phase Reactants
Aleksander Koj
- pp 73-131
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TLDR
The term acute phase reactants (AP-reactants) as discussed by the authors is used to refer to protein components of plasma whose concentration is significantly increased in the acute phase of inflammatory processes.Abstract:
The term “acute-phase reactants” (AP-reactants) is generally considered to refer to protein components of plasma whose concentration is significantly increased in the acute phase of inflammatory processes. This category includes several proteins with various physicochemical properties (Table 4.1) and biological functions, but at least two common features may be ascribed to them: almost all contain significant amounts of carbohydrates and all are synthesized in liver parenchymal cells. Hence AP-reactants may be defined as trauma-inducible liver-produced plasma glycoproteins.read more
Citations
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The phenomenon of the acute phase response
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Alpha-1-acid glycoprotein.
TL;DR: The use of AGP transgenic animals enabled to address in vivo, functionality of responsive elements and tissue specificity, as well as the effects of drugs that bind to AGP and will be an useful tool to determine the physiological role ofAGP.
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Noncellular nonspecific defence mechanisms of fish
J. B. Alexander,George A. Ingram +1 more
TL;DR: Fish tissues and body fluids contain naturally occurring proteins or glycoproteins of non-immunoglobulin (Ig) nature that react with a diverse array of environmental antigens and may confer an undefined degree of natural immunity to fish.
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Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1.
TL;DR: Data provide direct evidence that a single mediator, IL-1, can effect the positive and negative changes in specific hepatic gene expression characteristic of the acute phase response.
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Complete sequence of the cDNA for human .alpha.1-antitrypsin and the gene for the S variant
TL;DR: The position and size of introns, the overall base composition, and the codon preference for the alpha 1-anti-trypsin gene differ from those for the chicken ovalbumin gene even though the two proteins belong to a common protein family, as judged by amino acid sequence homology.
References
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Journal ArticleDOI
Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
The thiobarbituric acid assay of sialic acids.
TL;DR: This chapter discusses the different aspects of thiobarbituric acid assay of sialic acid, which is suitable for measuring the release of bound sialoic acid by sialidase and hydrolysis of sIALic acid-containing material must be carried out for the measurement of total sialsic acids.
Journal ArticleDOI
Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.
TL;DR: A new method for the quantitive determination of sialic acids is described, which is about 50% more sensitive than the orcinol-hydrochloric acid method generally used and considerably lower with the resorcin reagent.
Journal ArticleDOI
Crystalline soybean trypsin inhibitor : ii. general properties.
TL;DR: Crystalline soy protein when denatured is readily digestible by pepsin, and less readily by chymotrypsin and by trypsin, which results in a proportional gain in the inhibiting activity.