Altered functional connectivity of amygdala underlying the neuromechanism of migraine pathogenesis.
TLDR
The altered functional connectivity of amygdala demonstrated that neurolimbic pain network contribute in the EM pathogenesis and CM chronicization.Abstract:
The amygdala is a large grey matter complex in the limbic system, and it may contribute in the neurolimbic pain network in migraine. However, the detailed neuromechanism remained to be elucidated. The objective of this study is to investigate the amygdala structural and functional changes in migraine and to elucidate the mechanism of neurolimbic pain-modulating in the migraine pathogenesis. Conventional MRI, 3D structure images and resting state functional MRI were performed in 18 normal controls (NC), 18 patients with episodic migraine (EM), and 16 patients with chronic migraine (CM). The amygdala volume was measured using FreeSurfer software and the functional connectivity (FC) of bilateral amygdala was computed over the whole brain. Analysis of covariance was performed on the individual FC maps among groups. The increased FC of left amygdala was observed in EM compared with NC, and the decreased of right amygdala was revealed in CM compared with NC. The increased FC of bilateral amygdala was observed in CM compared with EM. The correlation analysis showed a negative correlation between the score of sleep quality (0, normal; 1, mild sleep disturbance; 2, moderate sleep disturbance; 3, serious sleep disturbance) and the increased FC strength of left amygdala in EM compared with NC, and a positive correlation between the score of sleep quality and the increased FC strength of left amygdala in CM compared with EM, and other clinical variables showed no significant correlation with altered FC of amygdala. The altered functional connectivity of amygdala demonstrated that neurolimbic pain network contribute in the EM pathogenesis and CM chronicization.read more
Citations
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The pathophysiology of migraine: implications for clinical management.
TL;DR: The identification of new migraine-associated genes, the visualisation of brain regions that are activated at the earliest stages of a migraine attack, and the recognition of the crucial role for neuropeptides are among the advances that have led to novel targets for migraine therapy.
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Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain
Edita Navratilova,Guangchen Ji,Caroline E. Phelps,Chaoling Qu,Matthew Hein,Vadim Yakhnitsa,Volker Neugebauer,Frank Porreca +7 more
TL;DR: Testing the hypothesis that KOR circuits in the central nucleus of the amygdala (CeA) undergo neuroplasticity in chronic neuropathic pain resulting in increased sensory and affective pain responses found that nor-BNI eliminated the aversiveness of ongoing pain.
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Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study.
TL;DR: CM patients have a stronger connectivity in the pain matrix than do EM patients, and functional alteration of the pain network might play a role in migraine chronification.
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Brain functional connectivity in headache disorders: A narrative review of MRI investigations:
TL;DR: Current rs-fMRI studies in headache disorders including migraine, trigeminal autonomic cephalalgias, and medication overuse headache are reviewed to show that headache disorders are associated with atypical functional connectivity of regions associated with pain processing as well as atypicals functional connectivityof multiple core resting state networks such as the salience, sensorimotor, executive, attention, limbic, visual, and default mode networks.
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Chronic migraine: A process of dysmodulation and sensitization.
Min Su,Shengyuan Yu +1 more
TL;DR: The latest data is reviewed to outline the clinical feature, pathophysiological mechanism, and management of chronic migraine, in the expectation to provide direction for future research and finally to take good care of Chronic migraine patients.
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