Journal ArticleDOI
Amiodarone and the thyroid
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This article is published in The Lancet.The article was published on 1979-04-07. It has received 145 citations till now. The article focuses on the topics: Wolff–Chaikoff effect & Thyroid.read more
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Journal ArticleDOI
2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum
Erik K. Alexander,Elizabeth N. Pearce,Gregory A. Brent,Rosalind S. Brown,Herbert Chen,Chrysoula Dosiou,William A. Grobman,Peter Laurberg,John Lazarus,Susan J. Mandel,Robin P. Peeters,Scott Sullivan +11 more
TL;DR: The revised guidelines for the management of thyroid disease in pregnancy include recommendations regarding the interpretation of thyroid function tests in pregnancy, iodine nutrition, thyroid autoantibodies and pregnancy complications, thyroid considerations in infertile women, hypothyroidism in pregnancy and thyrotoxicosis in pregnancy.
Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum The American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum
Alex Stagnaro-Green,Marcos Abalovich,Erik K. Alexander,Fereidoun Azizi,Jorge H. Mestman,Roberto Negro,Angelita Nixon,Elizabeth N. Pearce,Offie P. Soldin,Wilmar M. Wiersinga +9 more
TL;DR: Pregnancy is a stress test for the thyroid, resulting in hypothyroidism in women with limited thyroidal reserve or iodine deficiency, and postpartum thyroiditis inWomen with underlying Hashimoto’s disease who were euthyroid prior to conception.
Journal ArticleDOI
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis
Douglas S. Ross,Henry B. Burch,David S. Cooper,M. Carol Greenlee,Peter Laurberg,Ana Luiza Maia,Scott A. Rivkees,Mary H. Samuels,Julie Ann Sosa,Marius N. Stan,Martin A. Walter +10 more
TL;DR: One hundred twenty-four evidence-based recommendations were developed to aid in the care of patients with thyrotoxicosis and to share what the task force believes is current, rational, and optimal medical practice.
Journal ArticleDOI
The clinical significance of subclinical thyroid dysfunction.
TL;DR: The mechanisms underlying tissue alterations in SCTD and the effects of replacement therapy on progression and tissue parameters are examined, and the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's age is addressed.
Journal ArticleDOI
Thyroid disease and the heart
TL;DR: Hyperthyroidism is a common condition with a prevalence of approximately 1%; it affects predominantly women aged 30–50 years and is usually caused by Graves' disease, which is characterised by diffuse goitre, orbitopathy, pretibial myxoedema, and the presence of stimulating thyrotrophin (TSH) receptor antibody in the serum.
References
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Journal ArticleDOI
Diversion of peripheral thyroxine metabolism from activating to inactivating pathways during complete fasting.
Apostolos G. Vagenakis,Albert G. Burger,Gary I. Portnay,Merritt Rudolph,J. T. O'Brain,Fereidoun Azizi,Ronald A. Arky,Pascal Nicod,S. H. Ingbar,Lewis E. Braverman +9 more
TL;DR: The findings indicate that caloric deprivation results in an alteration in peripheral T4 metabolism away from generation of T3 and toward the generation of rT3, where the former is more active than T4, and the latter is essentially inactive.
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Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones.
TL;DR: It is suggested that amiodarone changes thyroid hormone metabolism, possibly by reducing deiodination of T4 to T3 and inducing a preferential production of rT3 and increasing the response of TSH to TRH.
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Iodide-induced thyrotoxicosis in Boston.
Apostolos G. Vagenakis,Chiu-an Wang,Albert G. Burger,Farahe Maloof,Lewis E. Braverman,Sidney H. Ingbar +5 more
TL;DR: Hyperthyroidism developed during and after iodide administration in four of the eight patients with nontoxic goiter in Boston, suggesting that the homeostatic mechanism controlling thyroid hormone synthesis and release in these patients is not functioning normally.
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Iodine-induced thyrotoxicosis in apparently normal thyroid glands.
TL;DR: Evidence is presented that thyrotoxicosis appeared during treatments by iodide or organic-iodine-containing drugs, in the absence of any past history of thyroid disorder, and was accompanied by almost undetectable radioidine uptake which nevertheless could be activated by TSH.
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Necrosis of follicular cells and discharge of thyroidal iodine induced by administering iodide to iodine-deficient dogs.
Bruce E. Belshaw,David V. Becker +1 more
TL;DR: Susceptibility to the cytotoxic effect of excess iodide appears to be related to certain kinetic characteristics of the iodine-deficient gland.