Journal ArticleDOI
An Appraisal of Genetic Studies on Leprosy
TLDR
A review of the research lines which have been explored to evaluate to what extent genetic factors are intervening on the mechanism of resistance and susceptibility to leprosy is presented in this article.Abstract:
The present paper reviews the research lines which have been explored to evaluate to what extent genetic factors are intervening on the mechanism of resistance and susceptibility to leprosy. It presents a critical discussion of the investigations on the familial association of leprosy, familial association of leprosy types, intrafamilial contagion of leprosy, concordance of leprosy in twinpairs, racial differences on leprosy prevalence and lepromatous rate, pedigree studies, association of leprosy to genetic markers, Australia antigen, and dermatoglyphic patterns. Space was also allotted to review family and twin-pair studies on the Mitsuda reaction, as well as to the investigation on the in vitro behaviour of blood macrophages against killed M. leprae. Some areas in which further research on leprosy and genetics may be considered as prioritary are outlined with some detail.read more
Citations
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Journal ArticleDOI
Risk factors for the development of clinical leprosy among contacts, and their relevance for targeted interventions
TL;DR: It is concluded that targeted interventions should be aimed at close contacts of both MB and PB patients inside and outside the household, particularly when genetically related.
Journal ArticleDOI
HLA-DR-associated genetic control of the type of leprosy in a population from surinam.
TL;DR: The relationship between HLA phenotype and leprosy classification was studied in 73 unrelated patients and 92 healthy controls from a mixed Negroid-Caucasoid population originating from Surinam, South America to indicate that in this population an DR3-associated factor controls the type of the disease that develops after infection with Mycobacterium leprae.
Journal ArticleDOI
HLA and susceptibility to leprosy.
TL;DR: This review examines the evidence for involvement of MHC-associated factors in host immune response to Mycobacterium leprae by collating HLA studies of sporadic and familial leprosy and discussing possible HLA-related immunological mechanisms in determining host response.
Journal ArticleDOI
HLA-Linked Genes and Leprosy: A Family Study in Karigiri, South India
Paul E. M. Fine,Eva Wolf,Janet Pritchard,Bridget Watson,David J. Bradley,Hilliard Festenstein,C. J. G. Chacko +6 more
TL;DR: The findings from this study agree with those of two previous studies carried out among smaller populations is Surinam and Wardha, Maharashtra State, India, and suggest that a genetic determinant which is linked to the major HLA locus on chromosome 6 and which is probably recessive affects susceptibility to tuberculoid leprosy in humans.
Journal ArticleDOI
A time-dependent logistic hazard function for modeling variable age of onset in analysis of familial diseases.
TL;DR: The paper presents an extension of the regressive logistic models proposed by Bonney to address the problems of variable age‐of‐onset and time‐dependent covariates in analysis of familial diseases, and application of the method to familial leprosy data leads to results consistent with previous analysis performed using the unified mixed model.
References
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Journal Article
Classification of leprosy according to immunity. A five-group system.
D.S Ridley,W H Jopling +1 more
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A New Antigen in Leukemia Sera
TL;DR: Patients who receive large numbers of transfusions for anemia and other causes may develop precipitins in their blood, which were thought to be antibodies against serum lipoproteins which developed in the patients as a result of the repeated transfusions.
Journal ArticleDOI
A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis.
TL;DR: This work has reported the presence of an isoantigen of human sera, rare or absent in normal U. S. and northern European populations but relatively common in patients with leukemia, and its role in the development of leukemia is unclear.
Journal ArticleDOI
The modification of egg-yolk fats by sunflower-seed oil and the effect of such yolk fats on blood-cholesterol levels.
L. Horlick,J.B. O'Neil +1 more
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Particles associated with Australia Antigen in the Sera of Patients with Leukaemia, Down's Syndrome and Hepatitis
TL;DR: The precipitin band which forms between the haemophilia antiserum and the serum containing Australia antigen stains faintly with sudan black, indicating that the antigen contains lipid.