An approach to the total synthesis of welwistatin.
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TLDR
An approach to the total synthesis of the antimicrotubule agent welwistatin is described and key transformations include an intramolecular cyclization of acetic acid derivative 18 to give rise to indole 19.About:
This article is published in Organic Letters.The article was published on 2006-05-17 and is currently open access. It has received 72 citations till now. The article focuses on the topics: Antimicrotubule agent & Enone.read more
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Aiming for the Ideal Synthesis
Tanja Gaich,Phil S. Baran +1 more
TL;DR: This perspective presents a simple and informative definition of "ideality" and demonstrates its use during the self-evaluation of several syntheses from the laboratory.
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C-H activation: a complementary tool in the total synthesis of complex natural products.
David Y.-K. Chen,So Won Youn +1 more
TL;DR: Recently completed total syntheses showcasing creative and ingenious incorporation of C-Hactivation as a strategic manoeuver are compared with their "non-C-H activation" counterparts, illuminating a new paradigm in strategic synthetic design.
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Enamides: valuable organic substrates.
TL;DR: Enamides display a fine balance of stability and reactivity, which is now leading to their increasing use in organic synthesis, and recent examples of these compounds as substrates are discussed in this article.
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Metal-catalyzed amide bond forming reactions in an environmentally friendly aqueous medium: nitrile hydrations and beyond
TL;DR: A survey of metal-catalyzed synthetic approaches of amides conducted in an environmentally friendly aqueous medium is given in this paper, where a number of starting materials are used.
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Total Synthesis of Rubriflordilactone B
TL;DR: The first and asymmetric total synthesis of Rubriflordilactone A, a bisnortriterpenoid isolated from Schisandra rubriflora, has been accomplished in a convergent manner.
References
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Welwitindolinones, Unusual Alkaloids from the Blue-Green Algae Hapalosiphon welwitschii and Westiella intricata. Relationship to Fischerindoles and Hapalinodoles
Klemens Stratmann,Richard E. Moore,Rosanne Bonjouklian,Jack B. Deeter,Gregory M. L. Patterson,Stacey Shaffer,Charles D. Smith,Tim A. Smitka +7 more
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Enantioselective Total Syntheses of Welwitindolinone A and Fischerindoles I and G
Phil S. Baran,Jeremy M. Richter +1 more
TL;DR: The first total syntheses of welwitindolinone A and the most complex members of the f Fischerindole family, fischerindoles I and G, are reported.
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The catalytic hydration of nitriles to amides using a homogeneous platinum phosphinito catalyst
Talit Ghaffar,Adrian W. Parkins +1 more
TL;DR: In this paper, a homogeneous catalysts for the hydration of nitriles to amides are described, which contain a hydrogen bridged mono-anionic didentate phosphinito group, together with a third phosphine oxide ligand and a monodentate anionic ligand.
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A new homogeneous platinum containing catalyst for the hydrolysis of nitriles
Talit Ghaffar,Adrian W. Parkins +1 more
TL;DR: In this article, a mechanism involving intramolecular attack by a phosphine oxide on a nitrile within the co-ordination sphere of the platinum atom is suggested, which is an extremely active homogeneous catalyst for the hydration of nitriles to amides.
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Oxidized welwitindolinones from terrestrial fischerella spp
TL;DR: Three new alkaloids from two terrestrial Fischerella spp.