Journal ArticleDOI
An update on Curcuma as a functional food in the control of cancer and inflammation
TLDR
An update of new studies of curcumin activities as tested in anticancer models from 2011 to 2015 is presented, focusing on new ways to overcome its low bioavailability and data from clinical trials.Abstract:
Purpose of review Curcumin, commonly known as turmeric, is a spice that comes from the root Curcuma longa. The present article presents an update of new studies of curcumin activities as tested in anticancer models from 2011 to 2015. Recent findings Evidence from in-vitro and in-vivo research, together with clinical trials conducted over the past few decades, substantiates the potential of curcumin as an anticancer and anti-inflammatory agent. The development of formulations of curcumin in the form of nanoparticles, liposomes, micelles, or phospholipid complexes to enhance its bioavailability and efficacy are still in the early stages. Clinical trials with curcumin indicate safety, tolerability, and nontoxicity. However, the efficacy is questionable, based on the small numbers of patients in each study. Summary The laboratory and the clinical studies until 2011 were summarized in a review published in this journal. An update of the new studies and knowledge from 2011 to March 2015 focuses on new ways to overcome its low bioavailability and data from clinical trials.read more
Citations
More filters
Journal ArticleDOI
Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials.
TL;DR: A meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating IL-6 concentrations, and this effect appears to be more evident in patients with higher degrees of systemic inflammation.
Journal ArticleDOI
Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch
Haseeb Zubair,Shafquat Azim,Aamir Ahmad,Mohammad Aslam Khan,Girijesh Kumar Patel,Seema Singh,Ajay P. Singh +6 more
TL;DR: This work discusses select phytochemicals—curcumin, epigallocatechin-3-gallate (EGCG), resveratrol, plumbagin and honokiol—in the context of their reported effects on the processes of inflammation and oxidative stress, which play a key role in tumorigenesis.
Journal ArticleDOI
Are polyphenol antioxidants at the root of medicinal plant anti-cancer success?
Ayodeji B. Oyenihi,Carine Smith +1 more
TL;DR: Most plant products with consistently reported anti-cancer efficacy contains high levels of polyphenols or other potent antioxidants and their mechanisms of action correlate to that reported for isolated antioxidants in the context of cancer, suggesting that natural products may indeed become the panacea against this chronic disease.
Journal ArticleDOI
Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies.
TL;DR: Dietary micronutrients including lycopene, epigallocatechin gallate, sulforaphane, indole-3-carbinol, resveratrol, quercetin, curcumin & piperine play a key role in prostate cancer prevention and progression and therefore hold great promise for the future overall management of prostate cancer.
Journal ArticleDOI
Curcumin in depressive disorders: An overview of potential mechanisms, preclinical and clinical findings.
Fernanda Neutzling Kaufmann,Marta Gazal,Clarissa Ribeiro Bastos,Manuella P. Kaster,Gabriele Ghisleni +4 more
TL;DR: The cellular targets of curcumin relevant to psychiatric disorders and its effects in preclinical and clinical studies with depression, anxiety disorders and other psychiatric related conditions are summarized.
References
More filters
Journal ArticleDOI
Doxil®--the first FDA-approved nano-drug: lessons learned.
TL;DR: This review summarizes historical and scientific perspectives of Doxil development and lessons learned from its development and 20 years of its use and demonstrates the obligatory need for applying an understanding of the cross talk between physicochemical, nano-technological, and biological principles.
Journal ArticleDOI
Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer.
TL;DR: Current knowledge on liposome and nanoparticles offer increased precision in chemotherapeutic targeting of prostate cancer and new avenues for the treatment of breast cancer are reviewed.
Journal Article
Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer
Ricky A. Sharma,Heather R. McLelland,Kirsti A. Hill,Christopher R. Ireson,Stephanie A. Euden,Margaret M. Manson,Munir Pirmohamed,Lawrence J. Marnett,Andreas J. Gescher,William P. Steward +9 more
TL;DR: The results suggest that Curcuma extract can be administered safely to patients at doses of up to 2.2 g daily, equivalent to 180 mg of curcumin, and that larger clinical trials ofcurcumin has low oral bioavailability in humans and may undergo intestinal metabolism.
Journal ArticleDOI
Curcumin nanoformulations : A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment
TL;DR: Recent works on the design and development of nano-sized delivery systems for curcumin, including liposomes, polymeric nanoparticles and micelles, conjugates, peptide carriers, cyclodextrins, solid dispersions, lipid nanoparticlesand emulsions are summarized.
Journal ArticleDOI
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment
TL;DR: This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application ofCurcumin for the prevention and/or treatment of cancer.