Journal ArticleDOI
Analysis of Molecular Interaction of Drugs within β-Cyclodextrin Cavity by Solution-State NMR Relaxation.
TLDR
The report presents the possibility of utilizing NMR relaxation data, a more cost-effective experiment, to calculate internuclear distances in the case of drug-supramolecule complexes that are generally obtained by extremely time consuming two-dimensional nuclear Overhauser enhancement-based methods.Abstract:
The prime focus of the present study is to employ NMR relaxation measurement to address the intermolecular interactions, as well as motional dynamics, of drugs, viz., paracetamol and aspirin, encapsulated within the β-cyclodextrin (β-CD) cavity. In this report, we have attempted to demonstrate the applicability of nonselective (R1ns), selective (R1se), and bi-selective (R1bs) spin–lattice relaxation rates to infer dynamical parameters, for example, the molecular rotational correlation times (τc) and cross-relaxation rates (σij) of the encapsulated drugs. Molecular rotational correlation times of the free drugs were calculated using the selective relaxation rate in the fast molecular motion time regime (ωH2τc2 ≪ 1 and R1ns/R1se ≈ 1.500), whereas that of the 1:1 complexed drugs were found from the ratio of R1ns/R1se in the intermediate motion time regime (ωH2τc2 ∼ 1 and R1ns/R1se ≈ 1.054), and these values were compared with each other to confirm the formation of inclusion complexes. Furthermore, the cross-...read more
Citations
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β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery.
TL;DR: In vivo studies confirmed the nontoxicity and hemocompatibility of the nanoconjugates and site specific drug delivery due to folate conjugation and subsequent significant suppression in tumor growth was demonstrated by in vivo studies.
Journal ArticleDOI
Reaction Monitoring Using SABRE-Hyperpolarized Benchtop (1 T) NMR Spectroscopy
Olga Semenova,Peter M. Richardson,Andrew J. Parrott,Alison Nordon,Meghan E. Halse,Simon B. Duckett +5 more
TL;DR: A series of single-shot 1H NMR measurements are used to monitor the chemical changes that take place in solution through the lifetime of the hyperpolarized response, illustrating how low-cost low-field NMR measurement provide unique insight into a complex catalytic process through a combination of hyperpolarsization and relaxation data.
Journal ArticleDOI
Do Cyclodextrins Encapsulate Volatiles in Deep Eutectic Systems
Maria Enrica Di Pietro,Greta Colombo Dugoni,Monica Ferro,Alberto Mannu,Franca Castiglione,Margarida F. Costa Gomes,Sophie Fourmentin,Andrea Mele +7 more
TL;DR: In this article, renewable and nontoxic absorbents can now be designed to eliminate air pollutants such as volatile organic compounds (VOCs) from confined atmospheres, and new hybrid materials result from the resulting hybrid materials.
Journal ArticleDOI
Formulation and evaluation of β-cyclodextrin-mediated inclusion complexes of isoniazid scaffolds: molecular docking and in vitro assessment of antitubercular properties
TL;DR: The synthesis and evaluation of inclusion complexes between two poorly water soluble antitubercular agents and β-cyclodextrin were reported and molecular docking analysis identified the most favorable host–guest interactions in the inclusion complexes.
Journal ArticleDOI
Development of oral curcumin based on pH-responsive transmembrane peptide-cyclodextrin derivative nanoparticles for hepatoma
TL;DR: In this paper , a pH-responsive cyclodextrin derivative (R6H4-CMβCD) with cell-penetrating ability was successfully synthesized, and curcumin-loaded nanoparticles were developed to improve its efficacy in hepatoma.
References
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Journal ArticleDOI
Drug Delivery Systems: Entering the Mainstream
TL;DR: There is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.