Open AccessJournal Article
Anhydrous F-18 labeled eslemental flurine for radiopharmaceutical preparation.
TLDR
Interest in fluorine- 18 as a label in radiopharmaceutical studies has led to the development of a method for the production of decicuries of anhydrous 18F-F2 using the 20Ne(d, alpha) 18F reaction, and functions affecting yield--including target design, target-gas handling and purity--have been addressed.Abstract:
Interest in fluorine- 18 as a label in radiopharmaceutical studies has led to the development of a method for the production of decicuries of anhydrous 18F-F2 using the 20Ne(d, alpha) 18F reaction. The amount of anhydrous 18F-F2 that can be removed from the target is a function of target pressure and carrier cokncentration increasing with rising target pressure and decreasing with decreasing carrier concentration. At a target pressure of 24 atmospheres and a carrier concentration of 0.1% F2, nearly 95% of the theoretical yield of fluorine- 18 produced can be removed and up to 85% delivered through a 10o-m stainless steel tube to the reaction chamber. Other functions affecting yield--including target design, target-gas handling and purity--have been addressed. Thick target yields for 14.0- and 9.4-MeV deuterons on target were measured to be 82 and 67 mCl/microA at saturation. With the BNL 60-in. cyclotron, production okf 600-800 mCl of 18F-F2 with a specific activity of approximately 10 mCi/mumole has been in effect since 1976.read more
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Fluorine-18 radiochemistry, labeling strategies and synthetic routes.
TL;DR: The current radiosynthesis routes and strategies for 18F labeling of small molecules and biomolecules are described and the need for simple and efficient 18F-labeling procedures is described.
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Regional brain glucose metabolism in chronic schizophrenia. A positron emission transaxial tomographic study
TL;DR: While no whole-slice metabolic differences were apparent between groups, schizophrenics had significantly lower activity in the frontal lobes, relative to posterior regions, and the medicated and drug-free groups did not differ from one another in these regards.
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Positron emission tomography in the study of aging and senile dementia.
Steven H. Ferris,Mony J. de Leon,Alfred P. Wolf,Tibor Farkas,David R. Christman,Barry Reisberg,Joanna S. Fowler,Robert R. MacGregor,Alan I. Goldman,Ajax E. George,Shiran Rampal +10 more
TL;DR: The degree of diminution in metabolic activity in SDAT was highly correlated with objective measures of degree of cognitive impairment, demonstrating the feasibility and potential utility of the PET-FDG technique for studying regional brain function in normal aging and dementia.
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6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications.
Pieter L. Jager,Raman Chirakal,Christopher Marriott,Adrienne H. Brouwers,K. P. Koopmans,Karen Y. Gulenchyn +5 more
TL;DR: Current clinical applications in neuroendocrine tumors, including carcinoid tumors, pancreatic islet cell tumors, pheochromocytoma, paraganglioma, medullary thyroid cancer, hyperinsulinism, and various other clinical entities are provided.
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Initial and subsequent approach for the synthesis of 18FDG
Joanna S. Fowler,Tatsuo Ido +1 more
TL;DR: Advances have largely overcome the limitations of the 110-minute half-life of 18F so that 18FDG is now available to most regions of the United States from a number of central production sites, and avoids the need for an on-site cyclotron and chemistry laboratory and has opened up the use of 18 FDG to institutions that have a positron emission tomography scanner (or other imaging device) but no cyclotrons or chemistry infrastructure.
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