Journal ArticleDOI
Animal models to test drugs with potential antidiabetic activity.
TLDR
The available animal models of diabetes and some in vitro models which have been used as tools to investigate the mechanism of action of drugs with potential antidiabetic properties are reviewed to contribute to the researcher in the ethnopharmacology field to designs new strategies for the development of novel drugs to treat this serious condition.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2008-01-17. It has received 299 citations till now.read more
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The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations.
TL;DR: A review of medicinal plants traditionally used for diabetes management in Nigeria and ways in which their therapeutic potential can be properly harnessed for possible integration into the country's healthcare system are highlighted.
Journal ArticleDOI
Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity
TL;DR: The information provided in this review will help the researchers for the development of an alternative methods rather than insulin and oral hypoglycemic agents for the treatment of diabetes mellitus, which will minimize the complication associated with the diabetes and related disorder.
Journal Article
The discovery of insulin
TL;DR: It seems necessary, seventy five years later, to reconsider the chronology of the history and put Paolesco but also Collip at the right places much before Banting and Best to whom, by a curious misinterpretation of facts, was attributed the priority of this fundamental discovery.
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Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes
TL;DR: It is demonstrated that the 10% fructose-fed followed by 40 mg/kg of BWSTZ injected rat can be a new and alternative model for T2D and higher fluid intake, blood glucose, serum lipids, liver glycogen, liver function enzymes and insulin resistance and significantly lower body weight, oral glucose tolerance, number of pancreatic β-cells and pancreaticβ-cell functions (HOMA-β) of FR10 group.
Journal ArticleDOI
The role of triterpenes in the management of diabetes mellitus and its complications
TL;DR: Until now very few clinical studies have been concerned with the application of triterpenes in treating diabetes, but due to their great therapeutic potential, these compounds deserve special attention.
References
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Journal ArticleDOI
Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
TL;DR: Findings indicate that the "diabetes epidemic" will continue even if levels of obesity remain constant, and given the increasing prevalence of obesity, it is likely that these figures provide an underestimate of future diabetes prevalence.
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Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction
TL;DR: It is suggested that diabetic patients without previous myocardial infarction have as high a risk of myocardia infarctions as nondiabetic patients with previous my Cardiac Arrest.
Journal Article
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
TL;DR: The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin.
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Medicinal plants of India with anti-diabetic potential.
J.K Grover,S.P Yadav,V Vats +2 more
TL;DR: 45 plants and their products that have been mentioned/used in the Indian traditional system of medicine and have shown experimental or clinical anti-diabetic activity are reviewed.
Journal ArticleDOI
Animal models of diabetes mellitus.
D. A. Rees,John Alcolado +1 more
TL;DR: Animal models have been used extensively in diabetes research, and a large number of new animal models for the study of diabetes, including knock‐in, generalized knock‐out and tissue‐specific knockout mice are produced.