Journal ArticleDOI
Anthrax vaccines: past, present and future.
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TLDR
Most livestock vaccines in use throughout the world today for immunization against anthrax are derivatives of the live spore vaccine formulated by Sterne in 1937 and still use descendants of his strain 34F2, and room for development of a successor is discussed.About:
This article is published in Vaccine.The article was published on 1991-08-01. It has received 334 citations till now. The article focuses on the topics: Anthrax vaccines & Anthrax Vaccine Adsorbed.read more
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DissertationDOI
Manipulation of antigen presenting cells to enhance host immune responses to bacterial infection
Journal Article
Production of polycolonal antibody against domain 2-4 of protective antigen of Bacillus anthracis in laboratory animals
TL;DR: This document is intended to assist in the preparation of future studies of the determinants of infectious disease in the context of swine flu.
Journal ArticleDOI
Bioterrorismo y vacunas
Bacillus anthracis Spore Concentrations at Various Carcass Sites
TL;DR: From a group of investigations, results indicated B. anthracis virulence is related to clonality and the copy numbers per cell of the virulence plasmids, p XO1 and pXO2.
Journal ArticleDOI
Queries about vaccines containing squalene.
TL;DR: This correspondence considers some of the early history of squalene (a polyunsaturated hydrocarbon) as an immunostimulant, and its recent/projected use as an adjuvant to amplify the potency of anthrax and influenza vaccines.
References
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Journal ArticleDOI
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
TL;DR: It is shown here that EF is an adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1] produced by Bacillus anthracis in an inactive form and nearly equals that of the most active known cyclase.
Journal ArticleDOI
Evidence for plasmid-mediated toxin production in Bacillus anthracis.
TL;DR: It is likely that B. anthracis strains of temperature-sensitive plasmids which code for toxin structural or regulatory proteins are cured, like Pasteur vaccine strains, which were cured of their resident extrachromosomal gene pools by sequential passage of cultures.
Journal ArticleDOI
Differences in susceptibility of inbred mice to Bacillus anthracis.
TL;DR: The mouse model appears to be useful in studies on host resistance to anthrax and on the pathogenesis of the infection, especially when studies suggested that resistance to the Sterne strain is determined by a single dominant gene or gene complex.
Journal ArticleDOI
Field Evaluation of a Human Anthrax Vaccine.
Philip S. Brachman,Herman Gold,Stanley A. Plotkin,F. Robert Fekety,Milton Werrin,Norman R. Ingraham +5 more
TL;DR: This communication reports the data collected in a field study of a susceptible industrial population known to be chronically exposed to anthrax over a fouryear period.
Journal ArticleDOI
Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain.
TL;DR: Data suggest that the galE S. typhi Ty21a oral vaccine strain, which presumably stimulates the local immune system in the intestine, may also serve as a useful carrier for other antigenic determinants to protect against different intestinal infections.