Journal ArticleDOI
Anthrax vaccines: past, present and future.
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TLDR
Most livestock vaccines in use throughout the world today for immunization against anthrax are derivatives of the live spore vaccine formulated by Sterne in 1937 and still use descendants of his strain 34F2, and room for development of a successor is discussed.About:
This article is published in Vaccine.The article was published on 1991-08-01. It has received 334 citations till now. The article focuses on the topics: Anthrax vaccines & Anthrax Vaccine Adsorbed.read more
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Patent
Monoclonal antibodies for neutralizing anthrax toxin
TL;DR: Isolated monoclonal antibodies that bind and/or neutralize anthrax protective antigen (PA) are disclosed as well as hybridomas secreting such antibodies.
Journal ArticleDOI
Overcoming challenges of improving legacy biopharmaceutical processes
Ying Gao,David Gervais +1 more
Evaluation Of Immunogenicity Of Transgenic Chloroplast Derived Protect
TL;DR: Evaluation of anthrax vaccine given to nearly 400,000 US military personnel by Vaccine Adverse Event Reporting System (VAERS) showed adverse effects such as flu-like symptoms, local pain, large degree of inflammation, edema, malaise, rash, arthralgia, and headache following vaccination.
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Journal ArticleDOI
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
TL;DR: It is shown here that EF is an adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1] produced by Bacillus anthracis in an inactive form and nearly equals that of the most active known cyclase.
Journal ArticleDOI
Evidence for plasmid-mediated toxin production in Bacillus anthracis.
TL;DR: It is likely that B. anthracis strains of temperature-sensitive plasmids which code for toxin structural or regulatory proteins are cured, like Pasteur vaccine strains, which were cured of their resident extrachromosomal gene pools by sequential passage of cultures.
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Differences in susceptibility of inbred mice to Bacillus anthracis.
TL;DR: The mouse model appears to be useful in studies on host resistance to anthrax and on the pathogenesis of the infection, especially when studies suggested that resistance to the Sterne strain is determined by a single dominant gene or gene complex.
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Field Evaluation of a Human Anthrax Vaccine.
Philip S. Brachman,Herman Gold,Stanley A. Plotkin,F. Robert Fekety,Milton Werrin,Norman R. Ingraham +5 more
TL;DR: This communication reports the data collected in a field study of a susceptible industrial population known to be chronically exposed to anthrax over a fouryear period.
Journal ArticleDOI
Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain.
TL;DR: Data suggest that the galE S. typhi Ty21a oral vaccine strain, which presumably stimulates the local immune system in the intestine, may also serve as a useful carrier for other antigenic determinants to protect against different intestinal infections.