Anti-leukemic and immunomodulatory effects of fungal metabolites of Pleurotus pulmonarius and Pleurotus ostreatus on benzene-induced leukemia in Wister rats.
Reads0
Chats0
TLDR
The metabolites exhibited profound antileukemic potential by suppressing leukemia and demonstrating immunotherapeutic activities on animals after oral administration in various experimental groups.Abstract:
BACKGROUND The use of natural bioactive compounds in conventional chemotherapy is a new direction in cancer treatment that is gaining more research attention recently. Bioactive polysaccharides and polysaccharide-protein complexes from some fungi (edible mushrooms) have been identified as sources of effective and non-toxic antineoplastic agents. Selected oyster mushrooms (Pleurotus pulmonarius and P. ostreatus being local [Nigeria] and exotic strains, respectively) were cultured on a novel medium of yeast extract supplemented with an ethanolic extract of Annona senegalensis, and the antileukemic potential of their metabolites was studied. METHODS Leukemia was successfully induced in Wister rats by intravenous injection (0.2 mL) of a benzene solution every 2 days for 3 consecutive weeks. The aqueous solution of fungal metabolites (20 mg/mL) produced by submerged fermentation was orally administered (0.2 mL) before, during, and after leukemia induction. Leukemia burden was assessed by comparing the hematological parameters at baseline and after leukemia induction. The immunomodulatory potential of the metabolites was assessed by using a phagocytic assay (carbon clearance method). The ability to enhance leukopoiesis was assessed by using the total leukocyte count. RESULTS Leukemia induction resulted in significant anemia indices and leukocytosis (P<0.05) in the experimental rats. Both metabolites equally enhanced leukopoiesis and demonstrated phagocytic actions; P. ostreatus activity was significantly higher than that of P. pulmonarius (P<0.05). CONCLUSION The metabolites exhibited profound antileukemic potential by suppressing leukemia and demonstrating immunotherapeutic activities on animals after oral administration in various experimental groups.read more
Citations
More filters
Journal ArticleDOI
Harrison's Principles of Internal Medicine
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
Journal ArticleDOI
Promising anticancer activity of polysaccharides and other macromolecules derived from oyster mushroom (Pleurotus sp.): An updated review.
TL;DR: A review of the use of oyster mushrooms in different types of cancer treatment is presented in this article, which explores the immunomodulatory effects of polysaccharides, proteoglycans and polypeptides derived from oyster mushroom that boosts the immune system to overcome the limitation of traditional cancer therapies.
Journal ArticleDOI
Preclinical anticancer studies on the ethyl acetate leaf extracts of Datura stramonium and Datura inoxia
Bakht Nasir,Muhammad Waleed Baig,Muhammad Majid,Muhammad Majid,Syeda Masooma Ali,Muhammad Zafar Irshad Khan,Syeda Tayyaba Batool Kazmi,Ihsan-ul Haq +7 more
TL;DR: Comprehensive screening divulged the tremendous potential of selected species as potent source of natural anticancer agents in a variety of cancers particularly leukemia.
Journal ArticleDOI
Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents.
Patryk Nowakowski,Renata Markiewicz-Żukowska,Joanna Bielecka,Konrad Mielcarek,Monika Grabia,Katarzyna Socha +5 more
TL;DR: In this paper, a review aimed to collect and summarize all the available scientific data on the anti-cancer activity of mushroom extracts, which showed that mushroom extracts from 92 species, prepared using 12 different solvents, could reduce the viability of 38 various cancers.
Journal ArticleDOI
Immunoprophylactic potential of wheat grass extract on benzene-induced leukemia: An in vivo study on murine model
TL;DR: Methanol extract of wheatgrass demonstrated antileukemic potential that might be due to the presence of flavonoids and polyphenolics in it, which is a gift of nature given to mankind.
References
More filters
Book
Harrison's Principles of Internal Medicine
TL;DR: In this article, Cardinal Manifestations of Disease Genetics and Disease Clinical Pharmacology Nutrition Infectious Disease Disorders Of The Cardiovascular System Disorders Of the Kidney And Urinary Tract Disorders Of Gastrointestinal System Disorders of The Immune System, Connective Tissue And Joints Hematology And Oncology Endocrinology And Metabolism Neurologic Disorders Environmental And Occupational Hazards.
Journal ArticleDOI
Harrison's Principles of Internal Medicine
TL;DR: The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors.
Book
District Laboratory Practice in Tropical Countries, Part 1
TL;DR: Interestingly, district laboratory practice in tropical countries part 1 pt 1 that you really wait for now is coming.
Journal ArticleDOI
Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives (review).
TL;DR: Clinical intervention studies have demonstrated the therapeutic importance of correcting the hypercholesterolemia and the initial step in lowering cholesterol is a special diet low in fat and saturated fatty acids and rich in crude fibers.
Related Papers (5)
Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway
Andrej Jedinak,Daniel Sliva +1 more
Application of DNA from mushroom Pleurotus ostreatus for cancer biotherapy: a pilot study.
Shlyakhovenko,Kosak,Olishevsky S +2 more