Journal ArticleDOI
Antibodies to GAD in Japanese diabetic patients: a multicenter study.
TLDR
Anti-GAD are frequently detected by the RIA kit in patients with IDDM of short duration and this assay may be useful for population screening for IDDM and for better understanding of its pathogenesis.About:
This article is published in Diabetes Research and Clinical Practice.The article was published on 1995-06-01. It has received 53 citations till now. The article focuses on the topics: Impaired glucose tolerance & Gestational diabetes.read more
Citations
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Journal ArticleDOI
Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States
Ronald C.W. Ma,Juliana C.N. Chan +1 more
TL;DR: East Asian patients with type 2 diabetes have a higher risk of developing renal complications than Europeans and, with regard to cardiovascular complications, a predisposition for developing strokes and cancer is emerging as the other main cause of mortality.
Journal ArticleDOI
Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans.
TL;DR: Greater visceral adiposity precedes the development of type 2 diabetes in Japanese Americans and demonstrates an effect independent of fasting insulin, insulin secretion, glycemia, total and regional adiposity, and family history of diabetes.
Journal ArticleDOI
Fulminant Type 1 Diabetes: A nationwide survey in Japan
Akihisa Imagawa,Toshiaki Hanafusa,Yasuko Uchigata,Azuma Kanatsuka,Eiji Kawasaki,Tetsuro Kobayashi,Akira Shimada,Ikki Shimizu,Tetsuya Toyoda,Taro Maruyama,Hideichi Makino +10 more
TL;DR: Flu-like symptoms and pregnancy were more frequently observed in the fulminant than in the autoimmune group, and metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes.
Journal ArticleDOI
Diabetic autoimmune markers in children and adolescents with type 2 diabetes.
TL;DR: Absence of diabetes autoimmune markers is not a prerequisite for the diagnosis of type 2 diabetes in children and adolescents, and there was no significant correlation between any of the diabetes antibodies and obesity, presence of acanthosis nigricans, or family history of diabetes.
Journal ArticleDOI
Autoantibodies to glutamic acid decarboxylase in diabetic patients from a multi‐ethnic Australian community: the Fremantle Diabetes Study
TL;DR: In this article, ethnic/racial differences in the prevalence of serum antibodies to glutamic acid decarboxylase (GADA) and ICA512/IA-2 in diabetic patients from a large, urban community were investigated.
References
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Journal ArticleDOI
Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease.
J. Tuomilehto,G. Vidgren,L. Toivanen,Eva Tuomilehto-Wolf,Kimmo Kohtamäki,J. Stengård,Paul Zev Zimmet,Ian R. Mackay,Mj Rowley,P. Koskela +9 more
TL;DR: Anti-GAD is a valuable early predictive marker and is associated with a very high risk for development of IDDM, and was measured in prediabetic sera from 151 women aged 20-39 years with newly diagnosed diabetes mellitus who had been identified through a nationwide diabetes register.
Journal ArticleDOI
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Steinunn Baekkeskov,Henk-Jan Aanstoot,Stephan Christgai,Annette Reetz,Michele Solimena,Marilia Cascalho,Franco Folli,Hanne Richter-Olesen,Pietro De Camilli +8 more
TL;DR: The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM), has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA.
Book
Joslin's Diabetes Mellitus
TL;DR: This chapter discusses the development of islet development and utilisation, and the regulation of metabolism and its applications in the context of island development.
Journal ArticleDOI
Antibodies to Glutamic Acid Decarboxylase Reveal Latent Autoimmune Diabetes Mellitus in Adults With a Non—Insulin-Dependent Onset of Disease
TL;DR: In a proportion of adults who present with NIDDM, a slowly evolving autoimmune insulitis can be revealed by testing for anti-GAD, which could have important connotations not only for early intervention, but also for the correct classification of diabetes.
Journal ArticleDOI
Latent Autoimmune Diabetes Mellitus in Adults (LADA): the Role of Antibodies to Glutamic Acid Decarboxylase in Diagnosis and Prediction of Insulin Dependency
Paul Zimmet,Tiinamaija Tuomi,Ian R Mackay,Merrill J. Rowley,William J. Knowles,Cohen M,Lang Da +6 more
TL;DR: Testing for anti‐GAD in adult‐onset non‐obese diabetic patients should be a routine procedure in order to detect latent insulin‐dependency at the earliest possible stage, since this assay can assist in the correct classification of diabetes, and more appropriate therapy.