Journal ArticleDOI
Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus–pituitary–adrenal axis
TLDR
Geniposide possessed potent antidepressant-like properties that may be mediated by its effects on the HPA axis, and upregulated the hypothalamic GRα mRNA level and GRα protein expression in PVN, suggesting geniposid could recover the impaired GRα negative feedback on CRH expression and HPAaxis.About:
This article is published in European Neuropsychopharmacology.The article was published on 2015-08-01. It has received 105 citations till now. The article focuses on the topics: Adrenocorticotropic hormone & Corticosterone.read more
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Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability
TL;DR: The meta‐analysis indicated that theCUMS protocol is a robust animal model of depression and is strongly associated with anhedonic behavior in rodents, however, high heterogeneity was found in the single subgroup analysis, which was attributable to modification of the CUMS and sucrose preference protocols.
Journal ArticleDOI
The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels.
TL;DR: Evidence is reviewed that shows that while both chronic stress and exercise elevate basal CORT levels leading to increased secretion of CORT, the former is detrimental to cognition/memory, mood/stress coping, and brain plasticity, while the latter is beneficial.
Journal ArticleDOI
Cortisol and Major Depressive Disorder-Translating Findings From Humans to Animal Models and Back.
TL;DR: It is argued that the absolute level of cortisol is unreliable for predicting the efficacy of antidepressant treatment and it is proposed that future preclinical models should reliably produce exaggerated HPA axis responses to acute or chronic stress a priori, which may, or may not, alter baseline cortisol levels.
Journal ArticleDOI
Gardenia jasminoides Ellis: Ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine.
Liping Chen,Maoxing Li,Zhi-qiang Yang,Wendi Tao,Peng Wang,Xiuyu Tian,Xiaolin Li,Weigang Wang +7 more
TL;DR: Traditional uses, ethnopharmacology, phytochemistry, pharmacology, toxicity and industrial applications of Gardenia jasminoides Ellis are provided and several suggestions for future application prospects are proposed.
Journal ArticleDOI
Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat.
Zhang Cai,Yongping Zhang,Yu-Yu Li,Bai-Ping Liu,Hao-Yin Wang,Li Kangwei,Shannon Zhao,Cai Song +7 more
TL;DR: CUMS‐induced depression‐ and anxiety‐like behavior may result from an imbalance between M1 and M2 and suppressed astrocyte function, which is associated with behavioral normalization.
References
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Acute and Longer- Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
A. John Rush,Madhukar H. Trivedi,Stephen R. Wisniewski,Andrew A. Nierenberg,Jonathan W. Stewart,Diane Warden,George Niederehe,Michael E. Thase,Philip W. Lavori,Barry D. Lebowitz,Patrick J. McGrath,Jerrold F. Rosenbaum,Harold A. Sackeim,David J. Kupfer,James F. Luther,Maurizio Fava +15 more
TL;DR: The acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial are described and compared.
Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
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Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
TL;DR: Overall, the CMS procedure appears to be at least as valid as any other animal model of depression, and can be used to study problems that are extremely difficult to address by other means.
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Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant.
TL;DR: Rats exposed chronically to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions and DMI reduced blood corticosterone and glucose levels, but stress did not significantly alter either measure.
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Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants.
TL;DR: This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST), and showed that SSRIs are not false negatives in the FST.