Journal ArticleDOI
Antigen of “serum sickness” type of heterophile antibodies in human sera: Identification as gangliosides with N-glycolylneuraminic acid
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TLDR
The results indicate that “serum-sickness” antibodies react with a common disaccharide moiety of non-reducing end of the both glycosphingolipids.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1977-11-21. It has received 179 citations till now. The article focuses on the topics: Heterophile & Antigen.read more
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Journal ArticleDOI
Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
Takashi Angata,Ajit Varki +1 more
Book ChapterDOI
Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens
TL;DR: Aberrant glycosylation as such may be the basis of inappropriate cell/cell and cell/matrix interactions that may be reflected in the abnormal cell social behavior of tumor cells, such as uncontrolled cell growth, invasiveness, and metastatic potential.
Journal ArticleDOI
Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid
Pam Tangvoranuntakul,Pascal Gagneux,Sandra Diaz,Muriel Bardor,Nissi Varki,Ajit Varki,Elaine A. Muchmore +6 more
TL;DR: It is found that Neu5Gc is rare in poultry and fish, common in milk products, and enriched in red meats, and normal humans have variable amounts of circulating IgA, IgM, and IgG antibodies against Neu 5Gc, with the highest levels comparable to those of the previously known anti-α-galactose xenoreactive antibodies.
Journal ArticleDOI
Multifarious roles of sialic acids in immunity
Ajit Varki,Pascal Gagneux +1 more
TL;DR: This overview surveys examples of biological roles of sialic acids in immunity, with emphasis on an evolutionary perspective, given the breadth of the subject.
Journal ArticleDOI
The Molecular Basis for the Absence of N-glycolylneuraminic Acid in Humans
TL;DR: The results indicate that the human homologue of CMP-NeuAc hydroxylase is inactive because it lacks an N-terminal domain that is essential for enzyme activity.
References
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Journal ArticleDOI
Quantitative isolation of total glycosphingolipids from animal cells
TL;DR: The quantitative isolation of total glycosphingolipids from crude lipid extracts without contamination from other lipid classes is described and is useful for determination of microgram quantities of glycolipids derived from less than 1 ml of packed cells.
Journal ArticleDOI
Gangliosides of human myelin: sialosylgalactosylceramide (g7) as a major component
TL;DR: Observations suggest a metabolic relationship between G7 and either cerebroside or sulphatide, the third most abundant ganglioside on a molar basis, in adult human white matter.
Journal ArticleDOI
Gas–liquid chromatographic assay of lipid-bound sialic acids: measurement of gangliosides in brain of several species
Robert K. Yu,Robert W. Ledeen +1 more
TL;DR: The GLC method has been applied to analysis of the total brain ganglioside content of several species, and a general trend was observed toward decreasing levels in the lower vertebrates.
Related Papers (5)
Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum.
Alex Zhu,Rosa Hurst +1 more