Journal ArticleDOI
Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome
Connie S. Schmaljohn,Sherman E. Hasty,Joel M. Dalrymple,James W. LeDuc,Ho Wang Lee,C.-H. von Bonsdorff,M. Brummer-Korvenkontio,Antti Vaheri,Theodore F. Tsai,Helen L. Regnery,D. Goldgaber,Pyung Woo Lee +11 more
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TLDR
Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses.Abstract:
Hemorrhagic fever with renal syndrome (HFRS) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the Eurasian continent and Japan. Although HFRS has not been reported in North America, viruses that are antigenically similar to HFRS agents were recently isolated from rodents in the United States. Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses.read more
Citations
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Hantaviruses: A Global Disease Problem
TL;DR: Their ubiquity and potential for causing severe human illness make these viruses an important public health concern; the distribution, ecology, disease potential, and genetic spectrum are reviewed.
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A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease
TL;DR: Current concepts regarding the ecology of and disease associated with these serious human pathogens are presented and an integration of the ecology and evolution of these and other host-virus ecosystems through modeling and hypothesis-driven research with the risk of emergence, host switching/spillover, and disease transmission to humans.
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Hantavirus infections in Europe.
Olli Vapalahti,Jukka Mustonen,Åke Lundkvist,Heikki Henttonen,Alexander Plyusnin,Alexander Plyusnin,Antti Vaheri,Antti Vaheri +7 more
TL;DR: There are few available data about the clinical picture of confirmed Saaremaa infections, but epidemiological evidence suggests that it is less pathogenic than Dobrava, and that SaareMAa infections are more similar to nephropathia epidemica caused by Puumala.
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Hantaviruses: genome structure, expression and evolution.
TL;DR: The identification in 1993 of Sin Nombre virus (SN) as the causative agent of hantavirus-associated pulmonary syndrome (HPS) led to intensive search for further hantviruses and as a result today a total of as many as 16 well-established sero/genotypes may be listed.
Journal ArticleDOI
Uncovering the mysteries of hantavirus infections
Antti Vaheri,Tomas Strandin,Jussi Hepojoki,Tarja Sironen,Heikki Henttonen,Satu Mäkelä,Jukka Mustonen +6 more
TL;DR: The basic molecular properties and cell biology of hantaviruses are discussed and an overview of virus-induced pathology, in particular vascular leakage and immunopathology is offered.
References
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Journal ArticleDOI
Isolation of the Etiologic Agent of Korean Hemorrhagic Fever
TL;DR: Diagnostic increases in immunofluorescent antibodies occurred in 113 of 116 severe and 11 of 34 milder cases of clinically suspected Korean hemorrhagic fever and Convalescent-phase sera from four persons suffering a similar disease in the Soviet Union were also positive for antibodies.
Journal ArticleDOI
Direct chemical method for sequencing RNA.
TL;DR: Four different base-specific chemical reactions generate a means of directly sequencing RNA terminally labeled with 32P, which yields clean cleavage patterns for each purine and pyrimidine and allows a determination of the entire RNA sequence out to 100-200 bases from the labeled terminus.
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Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection.
M. Brummer-Korvenkontio,A. Vaheri,Tapani Hovi,C.-H. von Bonsdorff,J. Vuorimies,Tytti Manni,Kari Penttinen,Nils Oker-Blom,Juhani Lähdevirta +8 more
TL;DR: An indirect immunofluorescence test for detection of serum antibodies specific for nephropathia epidemica (NE) has been developed with use of acetone-fixed cryostat sections of the lungs of bank voles that had been trapped from the NE-endemic area in Finland as antigen.
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Preparative two-dimensional polyacrylamide gel electrophoresis of 32P-labeled RNA
R. De Wachter,Walter Fiers +1 more
TL;DR: The method has been applied to the complete separation of RNA fractions obtained after a preliminary gel electrophoresis of partial enzymic digests of 32P-labeled bacteriophage RNA.
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Isolation of Hantaan Virus, the Etiologic Agent of Korean Hemorrhagic Fever, from Wild Urban Rats
TL;DR: The results document the existence of an urban cycle for Hantaan virus, which had been suspected on the basis of the occurrence of sporadic urban cases in humans of KHF, and suggest that Rattus-borne HantaAn virus may be widely distributed in urban centers.