Journal ArticleDOI
Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).
TLDR
Seven peptides with antimicrobial activity were isolated from norepinephrine-stimulated skin secretions of the diploid clawed frog, Xenopus tropicalis, suggesting that the species are not closely related phylogenetically.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2001-11-26. It has received 84 citations till now. The article focuses on the topics: Antimicrobial peptides & Peptide sequence.read more
Citations
More filters
Journal ArticleDOI
Anti-microbial peptides: from invertebrates to vertebrates
TL;DR: This review focuses on AMPs forming α‐helices, β‐hairpin‐like β‐sheets, α‐helix/β‐sheet mixed structures from invertebrate and vertebrate origins, which show some promise for therapeutic use.
Journal ArticleDOI
Antimicrobial peptides from ranid frogs: taxonomic and phylogenetic markers and a potential source of new therapeutic agents.
TL;DR: The broad-spectrum antibacterial and antifungal activities of certain peptides, for example esculentin-1, ranalexin-1 and ranatuerin, together with their relatively low hemolytic activity, make them candidates for development into therapeutically useful anti-infective agents.
Journal ArticleDOI
Antimicrobial peptides from amphibian skin: an expanding scenario: Commentary
TL;DR: Results indicate new possibilities for the development of effective human therapeutics based on antimicrobial peptides and partially disclosed the biotechnological potential of these molecules.
Journal ArticleDOI
Host-defence peptides from the glandular secretions of amphibians: structure and activity
TL;DR: This review covers the literature on the subject of biologically active peptide from the glands of amphibians, which include neuropeptides, antimicrobial and anticancer active peptides, antiviral agents, fungicides and peptides which complex with Ca2+ calmodulin.
Journal ArticleDOI
Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations
TL;DR: Data is presented to show that antimicrobial peptides, produced in granular glands of the skin and released in high concentrations into skin secretions, are highly effective in inhibiting growth of B. dendrobatidis in vitro and may provide limited protection for some species.
References
More filters
Journal ArticleDOI
Action of antimicrobial peptides: two-state model.
TL;DR: This model provides plausible explanations for the experimental findings that the susceptibility of different bacteria to a peptide is not directly correlated to its binding affinity, different peptides preferentially kill different pathogens, and peptides exhibit varying levels of lytic activity against different eukaryotic cells.
Journal ArticleDOI
Peptides as weapons against microorganisms in the chemical defense system of vertebrates
Pierre Nicolas,Amram Mor +1 more
TL;DR: This secondary, chemical immune system provides vertebrates with a repertoire of small peptides that are promptly synthesized upon induction, easily stored in large amounts, and readily available for antimicrobial warfare.
Journal ArticleDOI
Antimicrobial peptides from amphibian skin: what do they tell us?
TL;DR: In amphibian skin secretions contain many biologically active compounds, such as biogenic amines, complex alkaloids, or peptides as mentioned in this paper, which are considered the effector molecules of innate immunity, acting as a first line of defense against bacterial infections.
Journal ArticleDOI
Evolution of duplicate genes in a tetraploid animal, Xenopus laevis.
TL;DR: The results indicate that both copies of a duplicate gene can be subject to purifying selection and thus support the hypothesis of selection against all genotypes containing a null allele at either of two duplicate loci.
Journal ArticleDOI
Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones.
TL;DR: In this article, the authors analysed the skin secretion of the South African frog Xenopus laevis using fast atom bombardment mass spectrometry and h.p.c. in the mass range 500-3200 Da.