Journal ArticleDOI
Antimicrobial polymers: mechanism of action, factors of activity, and applications
L. M. Timofeeva,N. A. Kleshcheva +1 more
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TLDR
This mini-review briefly highlights and summarizes the results of studies during the past decade and especially in recent years, which concern the mechanism of action of different antimicrobial polymers and non-leaching microbicidal surfaces, and factors influencing their activity and toxicity, as well as major applications of antimicrobialpolymers.Abstract:
Complex epidemiological situation, nosocomial infections, microbial contamination, and infection risks in hospital and dental equipment have led to an ever-growing need for prevention of microbial infection in these various areas. Macromolecular systems, due to their properties, allow one to efficiently use them in various fields, including the creation of polymers with the antimicrobial activity. In the past decade, the intensive development of a large class of antimicrobial macromolecular systems, polymers, and copolymers, either quaternized or functionalized with bioactive groups, has been continued, and they have been successfully used as biocides. Various permanent microbicidal surfaces with non-leaching polymer antimicrobial coatings have been designed. Along with these trends, new moderately hydrophobic polymer structures have been synthesized and studied, which contain protonated primary or secondary/tertiary amine groups that exhibited rather high antimicrobial activity, often unlike their quaternary analogues. This mini-review briefly highlights and summarizes the results of studies during the past decade and especially in recent years, which concern the mechanism of action of different antimicrobial polymers and non-leaching microbicidal surfaces, and factors influencing their activity and toxicity, as well as major applications of antimicrobial polymers.read more
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Journal ArticleDOI
Polymeric materials with antimicrobial activity
TL;DR: The state of the art in the field of antimicrobial polymeric systems during the last decade is described in this paper, where a classification of the different materials is carried out dividing basically those synthetic polymers that exhibit antimicrobial activity by themselves; those whose biocidal activity is conferred through their chemical modification; those that incorporate antimicrobial organic compounds with either low or high molecular weight; and those that involve the addition of active inorganic systems.
Journal ArticleDOI
Antibacterial surfaces: the quest for a new generation of biomaterials.
TL;DR: Several recent efforts to design a new generation of antibacterial surfaces, which are based on mimicking the surface nanotopography of natural surfaces, are considered.
Journal ArticleDOI
Antimicrobial Polymers in Solution and on Surfaces: Overview and Functional Principles
TL;DR: The present review considers the working mechanisms of antimicrobial polymers and of contact-active antimicrobial surfaces based on examples of recent research as well as on multifunctional antimicrobial materials.
Journal ArticleDOI
Antimicrobial Polymeric Materials with Quaternary Ammonium and Phosphonium Salts
Yan Xue,Huining Xiao,Yi Zhang +2 more
TL;DR: This review focuses on the state of the art of antimicrobial polymers with quaternary ammonium/phosphonium salts, and discusses the structure and synthesis method, mechanisms of antim antibiotic action, and the comparison of antimacterial performance between these two kinds of polymers.
Journal ArticleDOI
Cationic Antimicrobial Polymers and Their Assemblies
TL;DR: Antimicrobial polymers grafted or self-assembled to inert or non inert vehicles can yield hybrid antimicrobial nanostructures or films, which can act as antimicrobials by themselves or deliver bioactive molecules for a variety of applications.
References
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Journal ArticleDOI
The Chemistry and Applications of Antimicrobial Polymers: A State-of-the-Art Review
TL;DR: This article reviews the state of the art of antimicrobial polymers primarily since the last comprehensive review by one of the authors in 1996 and discusses the requirements of antim antibiotic polymers, factors affecting the antimicrobial activities, methods of synthesizing antimicrobialpolymers, major fields of applications, and future and perspectives in the field of antimicrobials.