Antisperm antibodies are more prevalent in men with low sperm motility.
TLDR
It is concluded that significantly more men with low sperm motility have antisperm antibodies and the functional significance of these antibodies warrants further investigation.Abstract:
Fifty-six men with low sperm motility (less than or equal to 40% of sperm with forward progression) who attended our infertility clinic were tested for antisperm antibodies (IgG and IgA) using the indirect immunobead test. Nineteen (34%) of these men were found to be positive (greater than 10% binding). This was significantly higher (P less than 0.01) than the incidence (5%) of antibodies in men who attended our infertility clinic with high sperm motility (greater than 40% of sperm with forward progression). It is concluded that significantly more men with low sperm motility have antisperm antibodies. The functional significance of these antibodies warrants further investigation.read more
Citations
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Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease.
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Prostasomes are mediators of intercellular communication: from basic research to clinical implications.
TL;DR: Ronquist G (University Hospital, Uppsala, Sweden).
References
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Journal ArticleDOI
Effect of sperm antibodies in males on human in vitro fertilization (IVF).
TL;DR: The results suggest that sperm autoantibodies, particularly those of IgA immunoglobulin class (determined by immunobead test) can interfere with IVF, and this provides a rationale for attempting to treat patients by reducing the proportion of antibody-coated sperm in vitro for future IVF cycles.
Journal ArticleDOI
Prognostic value of the postcoital test: prospective study based on time-specific conception rates
TL;DR: Time‐specific conception rates were studied prospectively after a carefully validated post‐coital test (PCT) in a consecutive series of 80 ovulatory women without any pelvic or seminal cause for their previous infertility.
Journal ArticleDOI
Sperm antibodies and human in vitro fertilization
TL;DR: It is confirmed that sperm antibodies from female sera can inhibit human IVF.
Journal ArticleDOI
The impact of antisperm antibodies on human infertility.
Journal ArticleDOI
Cyclic prednisolone therapy for male infertility associated with autoantibodies to spermatozoa.
William F. Hendry,Kathryn Treehuba,Louis Hughes,Jidka Stedronska,Jaroslava M. Parslow,John A.H. Wass,G. Michael Besser +6 more
TL;DR: A new corticosteroid regimen consisting of prednisolone, 40 mg daily, rising to 80 mg daily if antibody titers did not fall, given from days 1 to 10 of the partner's menstrual cycle, for up to nine cycles appears to be encouraging and suitable for further assessment in a prospective controlled trial.
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