G. Michael Besser

TL;DR: Assessment of specific or general tumor markers offers high sensitivity in establishing the diagnosis and can also have prognostic significance, and therapy with radionuclides may be used for tumors exhibiting uptake to a diagnostic scan, either after surgery to eradicate microscopic residual disease or later if conventional treatment or biotherapy fails.

TL;DR: Pegvisomant is an effective medical treatment for acromegaly and of the patients treated for 12 months or more, 87 of 90 (97%) achieved a normal serum IGF-1 concentration.

TL;DR: A variety of tests and imaging studies are necessary for the correct diagnosis of the EAS, but up to 20% of cases present a covert or occult EAS syndrome, and these cases require a prolonged follow-up, review, and repetition of diagnostic tests and scans.

TL;DR: IL-6, like IL-1, can exert a potent enhancing effect on the HPA by acutely stimulating the secretion of CRH-41 from the hypothalamus at a site above the level of the median eminence, at concentrations known to occur in human plasma and cerebrospinal fluid.

TL;DR: It is concluded that pituitary adenomas show a lower level of p 27 protein expression than the normal cells from which they are derived, with malignant transformation leading to complete loss of p27 immunoreactivity.