Anxiolytic and Anti-Stress Effects of Brain Prolactin: Improved Efficacy of Antisense Targeting of the Prolactin Receptor by Molecular Modeling
Reads0
Chats0
TLDR
Evidence is provided for a receptor-mediated attenuation of the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis by prolactin as a novel regulator of both emotionality and HPA axis reactivity.Abstract:
We provide the first evidence that prolactin is a neuromodulator of behavioral and neuroendocrine stress coping in the rat In virgin female and male rats, intracerebral infusion of ovine prolactin (oPRL) into the lateral cerebral ventricle (intracerebroventricular) exerted an anxiolytic effect on the elevated plus-maze in a dose-dependent manner (01 and 10 μg/5 μl; p 005, not significant; adjustment of target position after mRNA modeling, 72%; p < 005) Taken together, prolactin acting at brain level has to be considered as a novel regulator of both emotionality and HPA axis reactivityread more
Citations
More filters
Journal ArticleDOI
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Rainer Landgraf,Inga D. Neumann +1 more
TL;DR: This concept considers neuropeptides in the extracellular fluid of the brain rather than those in the cerebrospinal fluid or plasma as primary signals, triggering a variety of receptor-mediated effects, including those underlying behavioral and neuroendocrine regulation and psychopathology.
Journal ArticleDOI
The Oxytocin Receptor: From Intracellular Signaling to Behavior
Benjamin Jurek,Inga D. Neumann +1 more
TL;DR: The mechanisms of OXT expression and release, expression and binding of the OXTR in brain and periphery, OX TR-coupled signaling cascades, and their involvement in behavioral outcomes are discussed to assemble a comprehensive picture of the central and peripheral OXT system.
Journal ArticleDOI
Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women.
Markus Heinrichs,Markus Heinrichs,Gunther Meinlschmidt,Inga D. Neumann,Sabine Wagner,Clemens Kirschbaum,Ulrike Ehlert,Dirk H. Hellhammer +7 more
TL;DR: It is concluded that lactation in women, in contrast to that in rats, does not result in a general restraint of the hypothalamic-pituitary-adrenal axis response to a psychosocial stressor, and suckling is suggested to exert a short-term suppression of the cortisol response to mental stress.
Book ChapterDOI
Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis.
TL;DR: In the present chapter, the efforts to reveal the physiological significance of intracerebrally released oxytocin in rats with respect to the regulation of the HPA axis under basal and stress conditions as well as withrespect to behavioural stress responses are summarized.
Journal ArticleDOI
No stress please! Mechanisms of stress hyporesponsiveness of the maternal brain
TL;DR: Maternal stress adaptations are not only important for the healthy prenatal development of the offspring by preventing excessive glucocorticoid responses and in the promotion of postnatal maternal behaviour, but are also vital for the well‐being of the mother and her mental health.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5
TL;DR: It is shown here how the response of the immune system to repeated exposure to high-energy radiation affects its ability to discriminate between healthy and diseased tissue.
Journal ArticleDOI
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.
TL;DR: A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
Journal ArticleDOI
The role of corticotropin-releasing factor in depression and anxiety disorders
TL;DR: The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported.
Journal ArticleDOI
Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
Mark S. Kramer,N.R. Cutler,John P. Feighner,Ram K. Shrivastava,John Carman,John J. Sramek,Scott A. Reines,Guanghan Liu,Duane B. Snavely,Edwina Wyatt-Knowles,Jeffrey J. Hale,Sander G. Mills,Malcolm MacCoss,Christopher John Swain,Timothy Harrison,Raymond G. Hill,Franz Hefti,Edward M. Scolnick,Margaret A. Cascieri,Gary G. Chicchi,Sharon Sadowski,Angela Williams,Louise Hewson,David D. Smith,Emma J. Carlson,Richard Hargreaves,Nadia M.J. Rupniak +26 more
TL;DR: The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties was found to be correct.