Journal ArticleDOI
Arsenic undergoes significant speciation changes upon incubation of contaminated rice with human colon micro biota
TLDR
In vitro study of gut microbial metabolism affects As in different rice matrices suggested that presystemic metabolism by human gut micro biota should be neglected in risk assessment studies.About:
This article is published in Journal of Hazardous Materials.The article was published on 2013-11-15. It has received 40 citations till now. The article focuses on the topics: Arsenic.read more
Citations
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Journal ArticleDOI
The gut microbiome is required for full protection against acute arsenic toxicity in mouse models
TL;DR: The human gut microbiome protects mice from arsenic-induced mortality, with protection levels correlating with the relative abundance of the human commensal Faecalibacterium.
Journal ArticleDOI
Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy.
TL;DR: This review is a summary of the bidirectional relationship between HMs and gut microbiota and of the probiotic-based protective strategies against HM-induced gut dysbiosis, with reference to strategies used in the food industry or for medically alleviating HM toxicity.
Journal ArticleDOI
Xenobiotics: Interaction with the Intestinal Microflora
TL;DR: Emerging evidence is summarized that illustrates how xenobiotics can affect the gut microbiome structure, create functional changes to the Gut microbiome, and become biotransformed by the gut microbiota.
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Arsenic thiolation and the role of sulfate-reducing bacteria from the human intestinal tract
TL;DR: It is found that SRB of human gastrointestinal origin, through their ability to produce H2S, were necessary and sufficient to induce As thiolation and should be incorporated into toxicokinetic analysis carried out after As exposure.
Journal ArticleDOI
Gut Microbiome Perturbations Induced by Bacterial Infection Affect Arsenic Biotransformation
Kun Lu,Peter Hans Cable,Ryan Abo,Hongyu Ru,Michelle E. Graffam,Katherine Ann Schlieper,Nicola Parry,Stuart S. Levine,Wanda Bodnar,John S. Wishnok,Miroslav Styblo,James A. Swenberg,James G. Fox,Steven R. Tannenbaum +13 more
TL;DR: In this article, the authors used an animal model with an altered gut microbiome induced by bacterial infection, 16S rRNA gene sequencing, and inductively coupled plasma mass spectrometry-based arsenic speciation to examine the effect of gut microbiome perturbations on the biotransformation of arsenic.
References
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Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water.
TL;DR: A significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers, and the multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.
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The gastrointestinal microbiota as a site for the biotransformation of drugs
TL;DR: The objective of this review is the provision of a comprehensive overview of the gastrointestinal microbiota, their drug substrates and metabolic mechanisms, and approaches to studying this further are discussed.
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The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update.
TL;DR: The role of metabolism in modulation of toxicity and carcinogenicity of arsenic has profoundly changed research into the metabolism and biological effects of arsenic.
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Inorganic arsenic in Chinese food and its cancer risk.
TL;DR: It is concluded that rice may be the largest contributor of iAs through food route for the Chinese people, and the population from the South has greater cancer risk than that from the North and the whole population.
Journal ArticleDOI
Validation of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Reactor Using Microorganism-associated Activities
TL;DR: The results obtained by the various validation experiments indicate that the SHIME reactor can be used to study the microbial communities of the gastrointestinal tract.