Ascending aorta dilation in association with bicuspid aortic valve: A maturation defect of the aortic wall
Nimrat Grewal,Adriana C. Gittenberger-de Groot,Robert E. Poelmann,Robert J.M. Klautz,J.H.N. Lindeman,Marie-José Goumans,Meindert Palmen,Salah A. Mohamed,Hans-Hinrich Sievers,Ad J.J.C. Bogers,Marco C. DeRuiter +10 more
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TLDR
The structure of the nondilated and dilated aortic wall in bicuspidy and tricuspid are intrinsically different, with the latter having more aspects of aging, including a defective smooth muscle cell differentiation possibly linked to lowered lamin A/C expression.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 2014-10-01 and is currently open access. It has received 66 citations till now. The article focuses on the topics: Bicuspid aortic valve & Smooth muscle cell differentiation.read more
Citations
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TGF-β Signaling in Control of Cardiovascular Function
TL;DR: The roles of T GF-β in vasculogenesis, angiogenesis, and lymphangiogenesis and the deregulation of TGF-β signaling in cardiovascular diseases are discussed.
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The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve-related aortopathy: Full online-only version
Michael A. Borger,Paul W.M. Fedak,Elizabeth H. Stephens,Thomas G. Gleason,Evaldas Girdauskas,John S. Ikonomidis,Ali Khoynezhad,Samuel C. Siu,Subodh Verma,Michael D. Hope,Duke E. Cameron,Donald F. Hammer,Joseph S. Coselli,Marc R. Moon,Thoralf M. Sundt,Alex J. Barker,Michael Markl,Alessandro Della Corte,Hector I. Michelena,John A. Elefteriades +19 more
TL;DR: Current guidelines cover all major aspects of bicuspid aortic valve aortopathy, including natural history, phenotypic expression, histology and molecular pathomechanisms, imaging, indications for surgery, surveillance, and follow-up, and recommendations for future research.
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Surgery for Aortic Dilatation in Patients With Bicuspid Aortic Valves A Statement of Clarification From the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Loren F. Hiratzka,Mark A. Creager,Eric M. Isselbacher,Lars G. Svensson,Rick A. Nishimura,Robert O. Bonow,Robert A. Guyton,Thoralf M. Sundt,Jonathan L. Halperin,Glenn N. Levine,Jeffrey L. Anderson,Nancy M. Albert,Sana M. Al-Khatib,Kim K. Birtcher,Biykem Bozkurt,Ralph G. Brindis,Joaquin E. Cigarroa,Lesley H. Curtis,Lee A. Fleisher,Federico Gentile,Samuel S. Gidding,Mark A. Hlatky,John S. Ikonomidis,Jose A. Joglar,Richard J. Kovacs,E. Magnus Ohman,Susan J. Pressler,Frank W. Sellke,Win Kuang Shen,Duminda N. Wijeysundera +29 more
TL;DR: A statement of clarification uses the ACC/AHA revised structure for delineating the Class of Recommendation and Level of Evidence to provide recommendations that replace those contained in Section 9.2.1 of the thoracic aortic disease guideline and Section 5.1.3 of the valvular heart disease guideline.
Journal ArticleDOI
Surgery for aortic dilatation in patients with bicuspid aortic valves: A statement of clarification from the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Loren F. Hiratzka,Mark A. Creager,Eric M. Isselbacher,Lars G. Svensson,Rick A. Nishimura,Robert O. Bonow,Robert A. Guyton,Thoralf M. Sundt +7 more
TL;DR: A statement of clarification uses the ACC/AHA revised structure for delineating the Class of Recommendation and Level of Evidence to provide recommendations that replace those contained in Section 9.2.1 of the thoracic aortic disease guideline and Section 5.1.3 of the valvular heart disease guideline.
Journal ArticleDOI
An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm.
Christian L. Lino Cardenas,Chase W. Kessinger,Yisha Cheng,Carolyn MacDonald,Tom MacGillivray,Brian B. Ghoshhajra,Luai Huleihel,Luai Huleihel,Saifar Nuri,Ashish Yeri,Farouc A. Jaffer,Naftali Kaminski,Patrick T. Ellinor,Neal L. Weintraub,Rajeev Malhotra,Eric M. Isselbacher,Mark E. Lindsay +16 more
TL;DR: It is shown that the formation of a HDAC9-MALAT1-BRG1 complex promotes VSMC dysfunction in TAA by epigenetically altering the expression of key components of the cytoskeleton in VSMCs.
References
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Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
TL;DR: The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normal development and maturation of the vasculature, as well as how these mechanisms/ processeses are altered in vascular injury or disease.
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2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: Executive summary: A report of the american college of cardiology foundation/american heart association task force on practice guidelines, american association for thoracic surgery, american college of radiology, american stroke association
Loren F. Hiratzka,George L. Bakris,Joshua A. Beckman,Robert M. Bersin,Vincent F. Carr,Donald E. Casey,Kim A. Eagle,Luke K. Hermann,Eric M. Isselbacher,Ella A. Kazerooni,Nicholas T. Kouchoukos,Bruce W. Lytle,Dianna M. Milewicz,David Reich,Souvik Sen,Julie A. Shinn,Lars G. Svensson,David M. Williams,Alice K. Jacobs,Sidney C. Smith,Jeffery L. Anderson,Cynthia D. Adams,Christopher E. Buller,Mark A. Creager,Steven M. Ettinger,Robert A. Guyton,Jonathan L. Halperin,Sharon A. Hunt,Harlan M. Krumholz,Frederick G. Kushner,Rick A. Nishimura,Richard L. Page,Barbara Riegel,William G. Stevenson,Lynn G. Tarkington,Clyde W. Yancy +35 more
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Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Jan Lammerding,P. Christian Schulze,Tomosaburo Takahashi,Serguei Kozlov,Teresa Sullivan,Roger D. Kamm,Colin L. Stewart,Richard T. Lee +7 more
TL;DR: The findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation.
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Bicuspid Aortic Valve Disease
TL;DR: This review summarizes the current understanding of the pathology, genetics, and clinical aspects of BAV disease with a focus on B AV disease in adulthood and demonstrates that life expectancy in adults with BAV Disease is not shortened when compared with the general population.
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Structural abnormalities of great arterial walls in congenital heart disease: light and electron microscopic analyses.
Koichiro Niwa,Joseph K. Perloff,Sunita Bhuta,Hillel Laks,Davis C. Drinkwater,John S. Child,Pamela D. Miner +6 more
TL;DR: Medial abnormalities in ascending aorta, paracoarctation aortsa, truncus arteriosus, and pulmonary trunk were prevalent in patients with a variety of forms of CHD encompassing a wide age range.