Asia-Pacific consensus guidelines on gastric cancer prevention.
Kwong Ming Fock,Nicholas J. Talley,Paul Moayyedi,Richard H. Hunt,Takeshi Azuma,Kentaro Sugano,Shu Dong Xiao,Shiu Kum Lam,Khean-Lee Goh,Tsutomu Chiba,Naomi Uemura,Jae G. Kim,Nayoung Kim,Tiing Leong Ang,Varocha Mahachai,Hazel M. Mitchell,Abdul Aziz Rani,Jyh-Ming Liou,Ratha korn Vilaichone,Jose D. Sollano +19 more
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TLDR
This work critically evaluated strategies for preventing gastric cancer in the Asia–Pacific region and found that conventional and innovative approaches to prevention are likely to be effective.Abstract:
Background and Aim: Gastric cancer is a major health burden in the Asia–Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate strategies for preventing gastric cancer.
Methods: A multidisciplinary group developed consensus statements using a Delphi approach. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded.
Results: Helicobacter pylori infection is a necessary but not sufficient causal factor for non-cardia gastric adenocarcinoma. A high intake of salt is strongly associated with gastric cancer. Fresh fruits and vegetables are protective but the use of vitamins and other dietary supplements does not prevent gastric cancer. Host–bacterial interaction in H. pylori infection results in different patterns of gastritis and differences in gastric acid secretion which determine disease outcome. A positive family history of gastric cancer is an important risk factor. Low serum pepsinogens reflect gastric atrophy and may be useful as a marker to identify populations at high risk for gastric cancer. H. pylori screening and treatment is a recommended gastric cancer risk reduction strategy in high-risk populations. H. pylori screening and treatment is most effective before atrophic gastritis has developed. It does not exclude the existing practice of gastric cancer surveillance in high-risk populations. In populations at low risk for gastric cancer, H. pylori screening is not recommended. First-line treatment of H. pylori infection should be in accordance with national treatment guidelines.
Conclusion: A strategy of H. pylori screening and eradication in high-risk populations will probably reduce gastric cancer incidence, and based on current evidence is recommended by consensus.read more
Citations
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Global Patterns of Cancer Incidence and Mortality Rates and Trends
TL;DR: Changing global incidence and mortality patterns for select common cancers and the opportunities for cancer prevention in developing countries are described.
Journal ArticleDOI
Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report
Peter Malfertheiner,Francis Mégraud,John Atherton,Anthony T. R. Axon,Franco Bazzoli,Gian Franco Gensini,Javier P. Gisbert,David Y. Graham,Ernst J. Kuipers +8 more
TL;DR: In this 4th edition of the Maastricht consensus report aspects related to the clinical role of H pylori were looked at again in 2010, with recommendations to guide doctors involved in the management of this infection associated with various clinical conditions.
Journal ArticleDOI
Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention
TL;DR: The epidemiology, screening, and prevention of gastric cancer are reviewed, including its incidence, survival, mortality, and trends over time, and risk factors are characterized, both environmental and genetic.
Journal ArticleDOI
Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial.
Kazutoshi Fukase,Mototsugu Kato,Shogo Kikuchi,Kazuhiko Inoue,Naomi Uemura,Shiro Okamoto,Shuichi Terao,Kenji Amagai,Shunji Hayashi,Masahiro Asaka +9 more
TL;DR: Prophylactic eradication of H pylori after endoscopic resection of early gastric cancer should be used to prevent the development of metachronous gastric carcinoma.
Journal ArticleDOI
Second Asia-Pacific Consensus Guidelines for Helicobacter Pylori Infection
K. Ming Fock,Peter H. Katelaris,Kentaro Sugano,Tiing Leong Ang,Richard H. Hunt,Nicholas J. Talley,Shiu Kum Lam,Shu Dong Xiao,Huck Joo Tan,Chun Ying Wu,Hyun Chae Jung,Bui Huu Hoang,Udom Kachintorn,Khean-Lee Goh,Tsutomu Chiba,Abdul Aziz Rani +15 more
TL;DR: It was recommended that H. pylori infection should be tested for and eradicated prior to long‐term aspirin or non‐steroidal anti‐inflammatory drug therapy in patients at high risk for ulcers and ulcer‐related complications and in communities with high incidence of gastric cancer prevention.
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