Association of GSTM1 and GSTT1 gene polymorphisms with COVID-19 susceptibility and its outcome.
Mohammad Abbas,Sushma Verma,Shrikant Verma,Sahabjada Siddiqui,Faizan Haider Khan,Syed Tasleem Raza,Zeba Siddiqi,Ale Eba,Farzana Mahdi +8 more
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This article is published in Journal of Medical Virology.The article was published on 2021-05-15 and is currently open access. It has received 23 citations till now.read more
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Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity
TL;DR: In this paper , a systematic search of all possible reports of genetic association with COVID-19 till April 07, 2022, and performed meta-analyses of all the genetic polymorphisms that were examined in at least three studies.
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Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactions
TL;DR: It is suggested that various genetic polymorphisms influence virus pathogenicity and host immunity, which might have significant implications for understanding and interpreting the matter of genetics in SARS‐CoV‐2 pathogenity and customized integrative medical care based on population investigation.
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Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review
Evangelia-Eirini Tsermpini,Una Glamočlija,Fulden Ulucan-Karnak,Sara Redenšek Trampuž,Vita Dolzan +4 more
TL;DR: The available literature and clinical trials are reviewed to extract the relevant genetic variants within the oxidative stress pathway associated with CO VID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.
Journal ArticleDOI
SOD2 rs4880 and GPX1 rs1050450 polymorphisms do not confer risk of COVID-19, but influence inflammation or coagulation parameters in Serbian cohort
Djurdja Jerotic,Jovan Ranin,Zoran Bukumiric,Tatjana Djukic,Vesna Coric,Ana Savic-Radojevic,Nevena Todorović,Milika Asanin,Marko Ercegovac,Ivana Milosevic,Marija Pljesa-Ercegovac,Goran Stevanovic,Marija Matic,Tatjana Simic +13 more
TL;DR: The findings regarding the influence of SOD2 and GPX1 polymorphisms on inflammation and coagulation parameters might be of clinical importance and could provide a more personalized approach for better recognition of patients prone to thrombosis and those for the need of targeted antioxidant therapy.
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Prevalence and mortality of COVID-19 are associated with the L55M functional polymorphism of Paraoxonase 1
TL;DR: The frequency of M55 was positively correlated with the prevalence of COVID-19 and mortality and this means that countries with higher M55 frequency have higher prevalence and mortality of CO VID-19.
References
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Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.
TL;DR: Non-mammalian GSTs have been much less well characterized, but have provided a disproportionately large number of three-dimensional structures, thus extending the authors' knowledge of glutathione transferases in mammals.
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Xiaowei Li,Xiaowei Li,Manman Geng,Manman Geng,Yizhao Peng,Yizhao Peng,Liesu Meng,Liesu Meng,Shemin Lu,Shemin Lu +9 more
TL;DR: A brief introduction of the general features of SARS-CoV-2 is provided and current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 is discussed, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS/MERS/CoV infection.
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Glutathione S-Transferase Polymorphisms and Their Biological Consequences
John D. Hayes,Richard C. Strange +1 more
TL;DR: Two supergene families encode proteins with glutathione S-transferase (GST) activity that detoxify a variety of electrophilic compounds, including oxidized lipid, DNA and catechol products generated by reactive oxygen species-induced damage to intracellular molecules.