Journal ArticleDOI
Association of metformin use with cancer incidence and mortality: A meta-analysis
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TLDR
Metformin can reduce the incidence of overall cancer, liver cancer, pancreatic cancer, colorectal cancer and breast cancer as well as the mortality of Overall cancer, Liver cancer and Breast cancer.About:
This article is published in Cancer Epidemiology.The article was published on 2013-06-01. It has received 242 citations till now. The article focuses on the topics: Cancer & Breast cancer.read more
Citations
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Sexual dimorphism in the incidence of human cancers
Daoshan Zheng,Justyna Trynda,Cecilia Williams,Jeremy A. Vold,Justin H. Nguyen,Denise M. Harnois,Sanjay P. Bagaria,Sarah A. McLaughlin,Zhaoyu Li +8 more
TL;DR: All human cancers had statistically significant sexual dimorphism with male dominance in the United States and mostly significant in the Mayo Clinic, Sweden, and the world data, except for thyroid cancer, which is female-dominant.
Journal ArticleDOI
Statins and Metformin Use Is Associated with Lower PSA Levels in Prostate Cancer Patients Presenting for Radiation Therapy.
Xiaonan Liu,Jing Li,Steven E. Schild,Michael H. Schild,William W. Wong,Sujay A. Vora,Michael G. Herman,Mirek Fatyga +7 more
TL;DR: It is found that statins and metformin were associated with lower PSA levels in prostate cancer patients to an extent that could influence management decisions.
Journal ArticleDOI
Mechanisms Linking Obesity and Thyroid Cancer Development and Progression in Mouse Models.
Won Gu Kim,Sheue-yann Cheng +1 more
TL;DR: This review focuses on molecular mechanisms by which obesity aggravates thyroid carcinogenesis as elucidated by mouse models of thyroid cancer.
Journal ArticleDOI
The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives.
TL;DR: The interactions of diabetes and obesity to PC development were summarized, and novel strategies for the prevention and treatment of Diabetes and PC were discussed.
BookDOI
Improving Outcomes for Breast Cancer Survivors
TL;DR: In this chapter, the authors introduce the topic of breast cancer survivorship and highlight the organization and content of this volume, briefl y describing the contents of the subsequent chapters.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
Journal ArticleDOI
The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
TL;DR: Those on insulin or insulin secretagogues were more likely to develop solid cancers than those on metformin, and combination with met formin abolished most of this excess risk.
Journal ArticleDOI
New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes
Gillian Libby,Louise A. Donnelly,Peter T. Donnan,Dario R. Alessi,Dario R. Alessi,Andrew D. Morris,Josie M M Evans +6 more
TL;DR: Results suggest that metformin use may be associated with a reduced risk of cancer in people with type 2 diabetes, and a randomized trial is needed to assess whether met formin is protective in a population at high risk for cancer.
Journal ArticleDOI
Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
Andrea Decensi,Matteo Puntoni,Pamela J. Goodwin,Massimiliano Cazzaniga,Alessandra Gennari,Bernardo Bonanni,Sara Gandini +6 more
TL;DR: A comprehensive literature search and meta-analysis of epidemiologic studies to assess the effect of metformin on cancer incidence and mortality in diabetic patients found that the inverse association was significant for pancreatic and hepatocellular cancer, and nonsignificant for colon, breast, and prostate cancer.
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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
I. Ben Sahra,Kathiane Laurent,Kathiane Laurent,Agnès Loubat,Agnès Loubat,Sophie Giorgetti-Peraldi,Sophie Giorgetti-Peraldi,Pascal Colosetti,Pascal Colosetti,Patrick Auberger,Patrick Auberger,Jean-François Tanti,Jean-François Tanti,Y. Le Marchand-Brustel,Y. Le Marchand-Brustel,Frédéric Bost,Frédéric Bost +16 more