Attitudes towards and participation in randomised clinical trials in oncology: A review of the literature
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TLDR
There is a paucity of research examining the association between knowledge about clinical trials, anxiety associated with a new cancer diagnosis and willingness to participate in randomised clinical trials.About:
This article is published in Annals of Oncology.The article was published on 2000-08-01 and is currently open access. It has received 265 citations till now. The article focuses on the topics: Clinical study design & Clinical trial.read more
Citations
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Participation rates in epidemiologic studies.
Sandro Galea,Melissa Tracy +1 more
TL;DR: The reasons why study participation has been declining are considered, what is known about who does participate in epidemiologic studies is summarized, and methods that may help improve study participation rates are discussed.
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Enrollment of Elderly Patients in Clinical Trials for Cancer Drug Registration: A 7-Year Experience by the US Food and Drug Administration
TL;DR: Elderly were under-represented in the registration trials of new cancer therapies and various strategies may be needed to evaluate cancer therapies for the elderly in prospective clinical trials and to improve cancer care in the elderly population.
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Systematic Review of Barriers to the Recruitment of Older Patients With Cancer Onto Clinical Trials
TL;DR: Specific clinical trials confined to older patients should be conducted to evaluate tumor biology, treatment tolerability, and the effect of comorbid conditions, and protocol designs need to stratify for age and be less restrictive with respect to exclusions on functional status,Comorbidity, and previous cancers, such that results are generalizable to Older patients.
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Barriers to Clinical Trial Participation by Older Women With Breast Cancer
Margaret Kemeny,Bercedis L. Peterson,Alice B. Kornblith,Hyman B. Muss,Judith Wheeler,Ellis Levine,Nancy L. Bartlett,Gini F. Fleming,Harvey J. Cohen +8 more
TL;DR: Age and stage were the only predictors of whether a patient was offered a trial in a multivariate analysis including comorbid conditions, and the physicians' perceptions about age and tolerance of toxicity were the greatest impediment to enrolling older women onto trials.
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Recruitment to randomised trials: strategies for trial enrolment and participation study. The STEPS study
Marion K Campbell,Claire Snowdon,David Francis,Diana Elbourne,Alison McDonald,Rosemary Knight,Vikki Entwistle,Jo Garcia,Ian Roberts,Adrian Grant +9 more
TL;DR: It is suggested that future trials should consider the different needs at different phases in the life of trials, and place greater emphasis on 'conduct' (the process of actually doing trials).
References
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Selection factors in clinical trials: results from the Community Clinical Oncology Program Physician's Patient Log.
Hunter Cp,Frelick Rw,Feldman Ar,Anne R. Bavier,Dunlap Wh,L G Ford,Donald E. Henson,Macfarlane D,Smart Cr,Yancik R +9 more
TL;DR: Age was a major factor influencing eligibility and entry on study, and a physician's preference for an alternate treatment and patient refusal for protocol treatment were important reasons that clinically eligible patients were not registered on protocol.
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Cancer Patients' Decision Making and Trial-entry Preferences The Effects of "Framing" Information about Short-term Toxicity and Long-term Survival
TL;DR: In this article, the framing of treatment information influenced patients' reported preferences for participating in treatment decision making and for trial entry and there was no difference across information groups in preference for participating or willingness to enter such a clinical trial.
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Attitudes of patients to randomised clinical trials of cancer therapy
TL;DR: The results show that the majority of subjects 287 (91.1%) believe that patients should be asked to take part in medical research, but only 242 (76.8%) would be prepared toTake part in a study comparing two treatments if treatment was randomised, and 119 (68.4%) of the 174 who initially said 'no' to randomisation or who were unsure, would change their minds and takePart in a trial.
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Volunteers or victims: patients' views of randomised cancer clinical trials
Maurice L. Slevin,J Mossman,A Bowling,R Leonard,William P. Steward,Peter Harper,M B McIllmurray,Nick Thatcher +7 more
TL;DR: This report suggests that patients themselves are willing to take part in clinical research, and are attracted by being treated by a doctor with a specialist interest in the disease and encouraged by the possibility that their progress will be monitored closely.
Journal Article
Effects of timing and reinforcement of preoperative education on knowledge and recovery of patients having coronary artery bypass graft surgery.
TL;DR: Patients in the experimental group had significantly higher preoperative knowledge levels, more positive mood states, and more favorable physiologic recoveries than those in the control group.