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Open AccessJournal ArticleDOI

Attitudes towards and participation in randomised clinical trials in oncology: A review of the literature

Peter M. Ellis
- 01 Aug 2000 - 
- Vol. 11, Iss: 8, pp 939-945
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TLDR
There is a paucity of research examining the association between knowledge about clinical trials, anxiety associated with a new cancer diagnosis and willingness to participate in randomised clinical trials.
About
This article is published in Annals of Oncology.The article was published on 2000-08-01 and is currently open access. It has received 265 citations till now. The article focuses on the topics: Clinical study design & Clinical trial.

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Citations
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Informeret samtykke i kliniske forsøg: teknikaliteter, tillid og tætte relationer

TL;DR: In this article, the authors explored patients' decisions about clinical trial participation in a group of patients with chronic conditions, focusing especially on motivation for trial participation and trial information, and argued that these patients’ decisions follow logics other than those anticipated in research ethics regulations.

Patients in Clinical Cancer Trials : Understanding, Motivation and Hope

TL;DR: The overall aim of this thesis was to study participants' understanding of clinical cancer trials, and their motivation for participation, and the question of whether the pat ...
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Factors affecting enrollment in a randomized controlled trial for Japanese metastatic breast cancer patients (SELECT BC-FEEL)--a prospective study.

TL;DR: Prospective studies are conducting prospective studies to identify the factors affecting the rates at which informed consent is obtained in selection of effective chemotherapy for breast cancer and breast cancer-CONFIRM.
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Exploring consent to randomized placebo-controlled clinical trials in oncology.

TL;DR: This study aimed to identify patient preferences for and satisfaction with three consultation styles in simulated discussions of four clinical trial concepts (randomization, placebo, tissue analysis and oncologists’ recommendation).
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Implementation and evaluation of a central coordination office for clinical trials in a tertiary care hospital

TL;DR: The establishment of a CCO for clinical trials substantially improves and maintains patient recruitment into clinical trials and improves the quality of clinical research.
References
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Evidence based medicine: what it is and what it isn't.

TL;DR: Evidence Based Medicine (IBM) as discussed by the authors is the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients, which is a hot topic for clinicians, public health practitioners, purchasers, planners and the public.
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Equipoise and the ethics of clinical research.

TL;DR: An alternative concept of equipoise is suggested, which would be based on present or imminent controversy in the clinical community over the preferred treatment, which is satisfied if there is genuine uncertainty within the expert medical community--not necessarily on the part of the individual investigator--about the preferredreatment.
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Information and participation preferences among cancer patients

TL;DR: Most patients in each age group displayed high levels of hope, preferences for open communication about their illness, and a desire for maximum amounts of information.
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Information Needs and Decisional Preferences in Women With Breast Cancer

TL;DR: Priorities for information identified in this study provide an empirical basis to guide communication with women seeking care for breast cancer and suggest systematic approaches to assess and respond to women's desired level of participation in treatment decision making need to be evaluated.
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Trending Questions (2)
How patients are enrolled in clinical trials?

Further research also is needed to evaluate strategies to better inform patients about clinical trials.

In which phase of clinical trials healthy volunteers are enrolled?

There are a variety of physician and patient characteristics which have previously been shown to influence participation in randomised clinical trials.