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Open AccessJournal ArticleDOI

Attitudes towards and participation in randomised clinical trials in oncology: A review of the literature

Peter M. Ellis
- 01 Aug 2000 - 
- Vol. 11, Iss: 8, pp 939-945
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TLDR
There is a paucity of research examining the association between knowledge about clinical trials, anxiety associated with a new cancer diagnosis and willingness to participate in randomised clinical trials.
About
This article is published in Annals of Oncology.The article was published on 2000-08-01 and is currently open access. It has received 265 citations till now. The article focuses on the topics: Clinical study design & Clinical trial.

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Citations
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A preoperative education intervention to reduce anxiety and improve recovery among Chinese cardiac patients: A randomized controlled trial

TL;DR: This form of preoperative education is effective in reducing anxiety and depression among Chinese cardiac surgery patients and should be incorporated into routine practice to prepare Chinese cardiac patients for surgery.
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Involving South Asian patients in clinical trials.

TL;DR: How South Asian patients conceptualise the notion of clinical trials is investigated and key processes that impact on trial participation are identified and the extent to which communication difficulties, perceptions of risk and attitudes to authority influence these decisions is identified.
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Effect of mindfulness training on asthma quality of life and lung function: a randomised controlled trial

TL;DR: MBSR produced lasting and clinically significant improvements in asthma-related quality of life and stress in patients with persistent asthma, without improvements in lung function.
Journal Article

Barriers and facilitators to participation of minorities in clinical trials.

TL;DR: Investigating barriers and facilitators that provide explanations for the low participation rate of women and minorities in clinical trials found that barriers to trial participation were reported at an appreciably higher rate than facilitators.
References
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Evidence based medicine: what it is and what it isn't.

TL;DR: Evidence Based Medicine (IBM) as discussed by the authors is the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients, which is a hot topic for clinicians, public health practitioners, purchasers, planners and the public.
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Equipoise and the ethics of clinical research.

TL;DR: An alternative concept of equipoise is suggested, which would be based on present or imminent controversy in the clinical community over the preferred treatment, which is satisfied if there is genuine uncertainty within the expert medical community--not necessarily on the part of the individual investigator--about the preferredreatment.
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Information and participation preferences among cancer patients

TL;DR: Most patients in each age group displayed high levels of hope, preferences for open communication about their illness, and a desire for maximum amounts of information.
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Information Needs and Decisional Preferences in Women With Breast Cancer

TL;DR: Priorities for information identified in this study provide an empirical basis to guide communication with women seeking care for breast cancer and suggest systematic approaches to assess and respond to women's desired level of participation in treatment decision making need to be evaluated.
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Trending Questions (2)
In which phase of clinical trials healthy volunteers are enrolled?

There are a variety of physician and patient characteristics which have previously been shown to influence participation in randomised clinical trials.

How patients are enrolled in clinical trials?

Further research also is needed to evaluate strategies to better inform patients about clinical trials.