Axon regeneration in the peripheral and central nervous systems.
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TLDR
Determinants of axon regeneration in the PNS and CNS are discussed, where both extracellular molecules and the intrinsic growth capacity of the neuron influence regenerative success.Abstract:
Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from that in the mammalian peripheral nervous system (PNS), where long-distance axon regeneration and substantial functional recovery can occur in the adult. Both extracellular molecules and the intrinsic growth capacity of the neuron influence regenerative success. This chapter discusses determinants of axon regeneration in the PNS and CNS.read more
Citations
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Nicholas M. Tran,Karthik Shekhar,Irene E. Whitney,Anne Jacobi,Inbal Benhar,Guosong Hong,Guosong Hong,Wenjun Yan,Xian Adiconis,McKinzie E. Arnold,Jung Min Lee,Joshua Z. Levin,Dingchang Lin,Chen Wang,Charles M. Lieber,Aviv Regev,Aviv Regev,Zhigang He,Joshua R. Sanes +18 more
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References
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Chondroitinase ABC promotes functional recovery after spinal cord injury
Elizabeth J. Bradbury,Lawrence D. F. Moon,Lawrence D. F. Moon,Reena J Popat,V.R. King,GS Bennett,Preena N. Patel,James W. Fawcett,Stephen B. McMahon +8 more
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Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
Samuel David,Albert J. Aguayo +1 more
TL;DR: The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model and the regenerative potential of these central neurons seems to be expressed when the central nervous System glial environment is changed to that of the peripheral nervous system.
Journal ArticleDOI
Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
M S Chen,A B Huber,M E van der Haar,Martin Frank,Lisa Schnell,Adrian Spillmann,Franziska Christ,Martin E. Schwab +7 more
TL;DR: Cl cloning of nogo A, the rat complementary DNA encoding NI-220/250 is reported, showing that Nogo-A is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity.
Journal ArticleDOI
Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
TL;DR: The IN-1 antibody, which recognizes NI35 and NI250(Nogo), allows moderate degrees of axonal regeneration and functional recovery after spinal cord injury, and provides a molecular basis to assess the contribution of Nogo to the failure ofAxonal regeneration in the adult CNS.
Journal ArticleDOI
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.
TL;DR: It is established that MAG is a significant, and possibly the major, inhibitor in CNS myelin; this has broad implications for axonal regeneration in the injured mammalian CNS.
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