Journal ArticleDOI
β-carbolines activate neurons in the substantia nigra pars reticulata: An effect reversed by diazepam and Ro15-1788
Reads0
Chats0
TLDR
The results indicate that beta-carbolines specifically influence the activity of SN-PR cells through a mechanism opposite to that of benzodiazepines themselves, acting on Benzodiazepine recognition sites.About:
This article is published in European Journal of Pharmacology.The article was published on 1983-12-09. It has received 18 citations till now. The article focuses on the topics: DMCM & Diazepam.read more
Citations
More filters
Journal ArticleDOI
Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.
Sandra E. File,Sharon Pellow +1 more
TL;DR: The purpose of the present review is to consider to what extent these intrinsic actions of Ro 15-1788 have implications for current concepts of the functioning of the benzodiazepine receptor.
Journal ArticleDOI
Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?
Giampaolo Mereu,Gian Luigi Gessa +1 more
TL;DR: The results indicate that ethanol might inhibit the firing of PR neurons through a GABAergic mechanism, and since PR neurons are thought to exert an inhibitory control on nigral dopaminergic neurons, it is suggested that the depression of the activity of such inhibitory interneurons may be responsible for ethanol-induced stimulation of dopamine activity.
Journal ArticleDOI
Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG 7142.
See-Ying Tam,Robert H. Roth +1 more
Journal ArticleDOI
Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration
TL;DR: It is indicated that midazolam differentially affects meso-accumbens and nigrostriatal DA neurons, and that the midazlam-induced decrease in extracellular DA in the nucleus accumbens is not affected by repeated drug administration.
Journal ArticleDOI
Functional in vivo correlates of the benzodiazepine agonist-inverse agonist continuum.
TL;DR: The present work focuses on the in vivo activities of benzodiazepine receptor ligands and investigates the role of receptor heterogeneity, which affects in vivo activity and the structure vs intrinsic activity of these ligands.
References
More filters
Journal ArticleDOI
Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors
Alessandro Guidotti,Concetta M. Forchetti,M. G. Corda,Dennis Konkel,Carl D. Bennett,Erminio Costa +5 more
TL;DR: DBI injected intraventricularly at doses of 5-10 nmol completely reversed the anticonflict action of diazepam on unpunished drinking and facilitated the shock-induced suppression of drinking by lowering the threshold for this response.
Journal ArticleDOI
Molecular mechanisms in the receptor action of benzodiazepines
Journal ArticleDOI
Interaction of convulsive ligands with benzodiazepine receptors.
TL;DR: During structural modification of ethyl beta-carboline-3-carboxylate an agent was discovered which has high affinity for brain benzodiazepine receptors but which is a potent convulsant, which may explain the convulsive properties.
Journal ArticleDOI
Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra.
TL;DR: D dopamine (DA)-containing and other output neurons of the substantia nigra (SN) wer identified by antidromic stimulation from postulated target nuclei, the caudate-putamen, the thalamus, the cortex and the pontine reticular formation to constitute a second, non-DA, fast-conducting nigrostriatal pathway.
Journal ArticleDOI
[3H]Propyl beta-carboline-3-carboxylate as a selective radioligand for the BZ1 benzodiazepine receptor subclass.
Claus Braestrup,Mogens Nielsen +1 more
TL;DR: Hofstee analyses of the shallow inhibition curves seen in hippocampus and cerebral cortex when [3H]FNM binding was inhibited by β‐CCE indicate that β‐ CCE and some other β‐carboline‐3‐carboxylate derivatives interact preferentially with a subclass of receptors, and that the percentage of this subclass is equivalent to the number of receptors labelled by [3h]PrCC.