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Bacterial pneumonias during an influenza pandemic: How will we allocate antibiotics?

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TLDR
The data on bacterial pneumonias during the 1918 influenza pandemic is summarized, the possible impact of a pandemic on the University of Michigan Health System is discussed, and the SRAC committee's guiding principles for allocating antibiotics during aPandemic are summarized.
Abstract
We are currently in the midst of the 2009 H1N1 pandemic, and a second wave of flu in the fall and winter could lead to more hospitalizations for pneumonia. Recent pathologic and historic data from the 1918 influenza pandemic confirms that many, if not most, of the deaths in that pandemic were a result of secondary bacterial pneumonias. This means that a second wave of 2009 H1N1 pandemic influenza could result in a widespread shortage of antibiotics, making these medications a scarce resource. Recently, our University of Michigan Health System (UMHS) Scarce Resource Allocation Committee (SRAC) added antibiotics to a list of resources (including ventilators, antivirals, vaccines) that might become scarce during an influenza pandemic. In this article, we summarize the data on bacterial pneumonias during the 1918 influenza pandemic, discuss the possible impact of a pandemic on the University of Michigan Health System, and summarize our committee's guiding principles for allocating antibiotics during a pandemic.

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Journal ArticleDOI

Bacterial and viral infections associated with influenza

TL;DR: A review was carried out of published articles covering bacterial and viral infections associated with pandemic and seasonal influenza between 1918 and 2009 to include both pulmonary and extra‐pulmonary infections to provide clinicians with an overview of the range ofacterial and viral co‐ or secondary infections that could present with influenza illness.
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Prospective Approach to Managing Antimicrobial Drug Shortages

TL;DR: Several resources are described to aid professionals in antimicrobial stewardship and healthcare epidemiology to manage drug shortages, including prospectively tracking shortages and maximizing inventory by appropriately managing usage.
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Influenza and Community-acquired Pneumonia Interactions: The Impact of Order and Time of Infection on Population Patterns

TL;DR: Animal studies most strongly support a single pathway of coinfection with influenza inoculation occurring approximately 7 days before inoculation with Streptococcus pneumoniae, but less-examined pathways of infection also may be important for human disease.
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Augmented adherence and internalization of group A Streptococcus pyogenes to influenza A virus infected MDCK cells.

TL;DR: It is revealed that IAV infection augments the adherence and internalization of GAS to MDCK cells via modulation of membrane associated O‐linked glycoproteins, fibrinogen, sialic acid residues and the mucin, MUC1 on the surface of M DCK cell.
References
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Journal ArticleDOI

Serial evaluation of the SOFA score to predict outcome in critically ill patients.

TL;DR: In this article, the authors evaluated the usefulness of repeated measurement of the Sequential Organ Failure Assessment (SOFA) score for prediction of mortality in intensive care unit (ICU) patients.
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Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

TL;DR: If severe pandemic influenza is largely a problem of viral-bacterial copathogenesis, pandemic planning needs to go beyond addressing the viral cause alone (e.g., influenza vaccines and antiviral drugs).