Journal ArticleDOI
Baseline GABA concentration and fMRI response
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TLDR
These findings demonstrate that both the dominant BOLD fMRI contrast, as well as other emerging MR hemodynamic contrasts, have signal variations that are linked to baseline GABA levels.About:
This article is published in NeuroImage.The article was published on 2010-11-01. It has received 169 citations till now. The article focuses on the topics: gamma-Aminobutyric acid.read more
Citations
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Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA
Paul G. Mullins,David J. McGonigle,Ruth L. O'Gorman,Nicolaas A.J. Puts,Nicolaas A.J. Puts,Rishma Vidyasagar,Christopher John Evans,Richard A.E. Edden,Richard A.E. Edden +8 more
TL;DR: A summary of the current 'state-of-the-art' in the field of GABA-edited MRS at 3T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA are provided.
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A Guide to the Metabolic Pathways and Function of Metabolites Observed in Human Brain 1H Magnetic Resonance Spectra
Caroline Rae,Caroline Rae +1 more
TL;DR: The current knowledge of the normal biochemistry of compounds that give rise to resonances in human brain proton magnetic resonance spectra measureable at readily available field strengths (i.e. ≤3 T) is reviewed.
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Advanced processing and simulation of MRS data using the FID appliance (FID-A)-An open source, MATLAB-based toolkit.
TL;DR: A new toolkit for simulation and processing of magnetic resonance spectroscopy data is introduced, and some of its novel features are demonstrated.
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GABA estimation in the brains of children on the autism spectrum: measurement precision and regional cortical variation
William Gaetz,Luke Bloy,Dah Jyuu Wang,Russell G. Port,Lisa Blaskey,Susan E. Levy,Timothy P.L. Roberts +6 more
TL;DR: The novel findings support the model of regional differences in GABA+/Cr in the ASD brain, primarily in Auditory and to a lesser extent Motor but not Visual areas.
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In vivo detection of GABA and glutamate with MEGA-PRESS: reproducibility and gender effects.
TL;DR: To evaluate the reproducibility of γ‐amino‐butyric acid (GABA) and glutamate concentrations derived using three different spectral fitting methods, and to investigate gender‐related differences in neurotransmitter levels.
References
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Neurophysiological investigation of the basis of the fMRI signal
TL;DR: These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output, and that LFPs yield a better estimate of BOLD responses than the multi-unit responses.
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Brain magnetic resonance imaging with contrast dependent on blood oxygenation
TL;DR: In this paper, the authors demonstrate in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level, which can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions.
Brainmagnetic resonance imaging withcontrast dependent on blood oxygenation
TL;DR: It is demonstrated that in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions.
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Estimation of metabolite concentrations from localized in vivo proton NMR spectra
TL;DR: The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model spectra of metabolite solutions in vitro by using complete model spectra, rather than just individual resonances, to ensure maximum information and uniqueness are incorporated into the analysis.
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What we can do and what we cannot do with fMRI
TL;DR: An overview of the current state of fMRI is given, and the current understanding of the haemodynamic signals and the constraints they impose on neuroimaging data interpretation are presented.