Journal ArticleDOI
Basement membrane and fibroblast aberration in blisters at the donor, graft, and spontaneously healed sites in patients with burns.
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TLDR
It is speculated that blister development in patients with burns is related to defective reorganization of the basement membrane zone in association with dermal fibroblast aberration during wound healing.Abstract:
• Background and Design— Blisters that developed on spontaneously healed wounds and grafts in 13 patients with burns were analyzed by light, fluorescence, and electron microscopy Results— Blisters developed on the dermal side of the dermoepidermal junction and occurred more frequently in donor site and healed mesh graft than in split-thickness sheet graft The four major components of the basement membrane zone (bullous pemphigoid antigen, laminin, type IV collagen, and epidermolysis bullosa acquisita antigen) were reduced in quantity and irregularly deposited at blister sites Immediately adjacent to the blisters, epidermolysis bullosa acquisita antigen appeared normal in quantity, while laminin, type IV collagen, and bullous pemphigoid antigen levels appeared slightly reduced Mononuclear infiltrates and autoantibodies were not detected by light microscopy or direct-indirect immunofluorescence, respectively Ultrastructurally, adjacent dermal fibroblasts demonstrated swollen rough endoplasmic reticulum and vacuolization Conclusions— We speculate that blister development in patients with burns is related to defective reorganization of the basement membrane zone in association with dermal fibroblast aberration during wound healing ( Arch Dermatol 1992;128:181-186)read more
Citations
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Journal ArticleDOI
Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns.
TL;DR: By providing a dermal replacement, the grafted dermal matrix permitted the use of a thin, widely meshed autograft from the donor site, without the undesirable scarring and contracture at the wound site that commonly results from this technique.
Journal ArticleDOI
Burn-induced linear IgA dermatosis
Girão L,Fiadeiro T,Rodrigues Jc +2 more
TL;DR: A case of burn‐induced LAD is presented in a 48‐year‐old caucasian male presenting with a recent history of blistering eruption on the periphery of a cicatricial area caused by boiling methyl alcohol.
Journal ArticleDOI
Delayed postburn blisters: an immunohistochemical and ultrastructural study.
Reuven Bergman,Rafael David,Ytzchak Ramon,Michal Ramon,Hedviga Kerner,Sigalit Kilim,Isaac J. Peled,Rachel Friedman-Birnbaum +7 more
TL;DR: The results of this study support discontinuity of the basement membrane as the main anomaly in delayed postburn blistering.
Journal ArticleDOI
Creation of an acellular dermal matrix from frozen skin
TL;DR: Results suggest that skin processed by the simple method has the potential to be used as a dermal template together with the cultured epidermis in the closure of full-thickness wounds.
Journal ArticleDOI
The use of an acellular matrix derived from human dermis for the treatment of full-thickness skin wounds
Elena Bondioli,Valeria Purpura,Catuscia Orlandi,Andrea Carboni,Paola Minghetti,Giovanna Cenacchi,Giovanni De Luca,Daniela Capirossi,Evandro Nigrisoli,Davide Melandri +9 more
TL;DR: The clinical use of a recently developed human dermal matrix (HDM) in combination with graft skin as an alternative reconstructive solution for the treatment of full-thickness skin wounds is described and Histological and ultra-structural analysis show a regenerative healing of the wound area with well-organized/oriented connective tissue.
References
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Journal ArticleDOI
Evidence for an Epidermal Cytokine Network
Thomas A. Luger,Thomas Schwarz +1 more
TL;DR: Understanding of cytokine interactions may be helpful in elucidating the pathomechanisms of such diseases, and certain cytokines, as well as their analogues and antagonists, may prove to be of therapeutic value.
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Formation of a supramolecular complex is involved in the reconstitution of basement membrane components
TL;DR: The studies show that the components of basement membrane interact in a highly specific manner and suggest that such interactions may be involved in the deposition of basement membranes in situ.
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Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta
TL;DR: It is suggested that IL 1 and TNF may play predominately a catabolic role in situ during dermal fibrotic responses by directly inhibiting fibronectin production and indirectly causing the degradation of collagen and glycosaminoglycan by significantly increasing Dermal fibroblast elaboration of collagenase and proteoglycanase activities.
Journal ArticleDOI
Hemidesmosomes and anchoring fibril collagen appear synchronously during development and wound healing.
TL;DR: Demonstrations of the synchronous assembly of hemidesmosomes and anchoring fibrils support the hypothesis of linkage of hemidsmosomes through the basement membrane to anchoring Fibrils.
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Characterization of avascular corneal wound healing fibroblasts. New insights into the myofibroblast.
TL;DR: In this paper, the authors evaluated the characteristics and derivation of corneal wound healing fibroblasts (myofibroblast) by studying the temporal changes in the cellular actin distribution.