Book ChapterDOI
Basic Substance Characteristics and Neuropathological Findings in Drug Abusers
Andreas Büttner
- pp 23-87
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TLDR
In this article, the major psychoactive component, ∆9tetrahydrocannabinol (∆9-THC), interacts with specific CB receptors in the brain.Abstract:
Cannabis is the most frequently abused recreational drug worldwide. Its major psychoactive component, ∆9-tetrahydrocannabinol (∆9-THC), interacts with specific cannabinoid (CB) receptors in the brain. Until today distinct neuropathological alterations have not been described.read more
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Journal ArticleDOI
Synthetic cathinones related fatalities: an update.
Simona Zaami,Raffaele Giorgetti,Simona Pichini,Flaminia Pantano,Enrico Marinelli,Francesco Paolo Busardò +5 more
TL;DR: Use of synthetic cathinones still represents a serious public health issue and Analytical methodologies for the identification of parent compounds and eventual metabolites both in ante-mortem and post-mortem cases need to be developed and validated.
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Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior
TL;DR: Galpha(i3)/betagamma/AGS3 appears to mediate mu opiate receptor activation of PKA signaling as well as heroin-seeking behavior in rats self-administering heroin.
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Recent paramethoxyamphetamine deaths
TL;DR: For example, this paper found that PMA appeared to be more toxic than MDMA, and blood levels greater than 0.5 mg/L seemed likely to be associated with toxic effects.
Journal ArticleDOI
Drug Abuse and Stroke
TL;DR: Toxicology screening for illicit drugs should be done in young patients with stroke with no obvious cause, or if suggested by history or examination, as well as in geographic areas with a high prevalence of illicit drug use.
Journal ArticleDOI
Cocaine-associated intracranial hemorrhage Absence of vasculitis in 14 cases
TL;DR: It is suggested that intracranial hemorrhages occur in the absence of readily detectable vascular abnormalities, with vasculitis and vasospasm as possible etiologies.